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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 934 - 940 (7page)
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초록· 키워드
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Objective Schizophrenia is one of the most devastating neuropsychiatric disorders. Genetic epidemiological studies have confirmed that schizophrenia is a genetic disease. Genes promoting neurodevelopment may be potential candidates for schizophrenia. As an adaptor linking a number of tyrosine kinase receptors in multiple intracellular signaling cascades, Src homology 2 domain containing transforming protein 3 (<i>SHC3</i>) is a member of the Shc-like adaptor protein family, and expressed predominantly in the mature neurons of the central nervous system (CNS). In the present study, we aimed to investigate the association of <i>SHC3</i> and schizophrenia.Methods An independent case-control association study was performed in a sample including 710 schizophrenia patients and 1314 healthy controls from a Northeast Chinese Han population.Results The allelic and genotypic association analyses showed that four SNPs in <i>SHC3</i> significantly associated with schizophrenia (rs2316280, rs4877041, rs944485 and rs7021743). The haplotype composing of these four SNPs also showed significantly individual and global association with schizophrenia.Conclusion Our present results suggest <i>SHC3</i> as a susceptibility gene for schizophrenia.
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참고문헌 (27)
참고문헌 신청
Saha S / 2005 / A systematic review of the prevalence of schizophrenia / PLoS Med 2:e141
Tandon R / 2008 / Schizophrenia, “just the facts”what we know in 2008. 2. Epidemiology and etiology / Schizophr Res 102:1~18
Ross CA / 2006 / Neurobiology of schizophrenia / Neuron 52:139~153
Cardno AG / 1999 / Heritability estimates for psychotic disorders : the Maudsley twin psychosis series / Arch Gen Psychiatry 56:162~168
International Schizophrenia Consortium / 2009 / Common polygenic variation contributes to risk of schizophrenia and bipolar disorder / Nature 460:748~752
Tandon R / 2008 / Schizophrenia, “just the facts”what we know in 2008. 2. Epidemiology and etiology / Schizophr Res 102:1~18
Ross CA / 2006 / Neurobiology of schizophrenia / Neuron 52:139~153
Cardno AG / 1999 / Heritability estimates for psychotic disorders : the Maudsley twin psychosis series / Arch Gen Psychiatry 56:162~168
International Schizophrenia Consortium / 2009 / Common polygenic variation contributes to risk of schizophrenia and bipolar disorder / Nature 460:748~752
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