지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 103 - 111 (9page)
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초록· 키워드
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ObjectiveaaEven though the role of the DICS1 gene as a risk factor for schizophrenia is still unclear, there is substantial evidence from functional and cell biology studies that supports the connection of the gene with schizophrenia. The studies associating the DISC1 gene with schizophrenia in Asian populations are limited to East-Asian populations. Our study examined several DISC1 markers of schizophrenia that were identified in the Caucasian and East-Asian populations in Malaysia and assessed the role of rs2509382, which is located at 11q14.3, the mutual translocation region of the famous DISC1 translocation [t (1; 11) (p42.1; q14.3)].
MethodsaaWe genotyped eleven single-neucleotide polymorphism (SNPs) within or related to DISC1 (rs821597, rs821616, rs4658971, rs1538979, rs843979, rs2812385, rs1407599, rs4658890, and rs2509382) using the PCR-RFLP methods.
ResultsaaIn all, there were 575 participants (225 schizophrenic patients and 350 healthy controls) of either Malay or Chinese ethnicity. The case-control analyses found two SNPs that were associated with schizophrenia [rs4658971 (p=0.030; OR=1.43 (1.35–1.99) and rs1538979-(p=0.036; OR=1.35 (1.02–1.80)] and rs2509382-susceptibility among the males schizophrenics [p=0.0082; OR=2.16 (1.22–3.81)]. This is similar to the meta-analysis findings for the Caucasian populations.
ConclusionaaThe study supports the notion that the DISC1 gene is a marker of schizophrenia susceptibility and that rs2509382 in the mutual DISC1 translocation region is a susceptibility marker for schizophrenia among males in Malaysia. However, the finding of the study is limited due to possible genetic stratification and the small sample size.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Bae JS / 2013 / Lack of association between DISC1 polymorphisms and risk of schizophrenia in a Korean population / Psychiatry Res 208 : 189 ~ 190
Cannon TD / 2005 / Association of DISC1/TRAX haplotypes with schizophrenia, reduced prefrontal gray matter, and impaired short- and long-term memory / Arch Gen Psychiatry 62
Carless MA / 2011 / Impact of DISC1 variation on neuroanatomical and neurocognitive phenotypes / Mol Psychiatry 16 : 1096 ~ 1104
Chen QY / 2007 / Case-control association study of Disrupted-in-Schizophrenia-1 (DISC1) gene and schizophrenia in the Chinese population / J Psychiatr Res 41 : 428 ~ 434
Chubb JE / 2008 / The DISC locus in psychiatric illness / Mol Psychiatry 13 : 36 ~ 64
Cannon TD / 2005 / Association of DISC1/TRAX haplotypes with schizophrenia, reduced prefrontal gray matter, and impaired short- and long-term memory / Arch Gen Psychiatry 62
Carless MA / 2011 / Impact of DISC1 variation on neuroanatomical and neurocognitive phenotypes / Mol Psychiatry 16 : 1096 ~ 1104
Chen QY / 2007 / Case-control association study of Disrupted-in-Schizophrenia-1 (DISC1) gene and schizophrenia in the Chinese population / J Psychiatr Res 41 : 428 ~ 434
Chubb JE / 2008 / The DISC locus in psychiatric illness / Mol Psychiatry 13 : 36 ~ 64
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