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논문 기본 정보

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학술저널
저자정보
Yuan-yuan Li (Department of Psychological Medicine Zhongshan Hospital Fudan University) Rui-jie Geng (Department of Psychological Medicine Zhongshan Hospital Fudan University) Shun-ying Yu (Department of Psychiatry Shanghai Mental Health Center Shanghai Jiao Tong University School of Medi) Guan-jun Li (Department of Psychiatry Shanghai Mental Health Center Shanghai Jiao Tong University School of Medi) Zhou-ye Wang (Department of Medical Psychology Xin Hua Hospital Affiliated to Shanghai Jiao Tong University Schoo) Hua-fang Li (Department of Psychiatry Shanghai Mental Health Center Shanghai Jiao Tong University School of Medi)
저널정보
대한신경정신의학회 PSYCHIATRY INVESTIGATION PSYCHIATRY INVESTIGATION 제18권 제10호
발행연도
2021.10
수록면
943 - 948 (6page)
DOI
10.30773/pi.2021.0151

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Objective To investigate the relation between nicotinic acetylcholine receptor subunit (nAChR) genes and schizophrenia, and the relation between tag single nucleotide polymorphism (rs1317286, rs1044396, rs6494212, rs16969968, and rs684513) and schizophrenia in Han Chinese people.Methods The protein-protein interaction (PPI) network among nAChR protein and 350 proteins encoded by schizophrenia-related susceptibility genes was constructed through the String database to explore whether nAChR genes were associated with schizophrenia in these known databases. Then, five single nucleotide polymorphisms (SNPs) of CHRNA3 (rs1317286), CHRNA4 (rs1044396), CHRNA7 (rs6494212), and CHRNA5 (rs16969968, rs684513) were analyzed in a sample of 1,035 schizophrenic patients and 816 healthy controls. The interaction between the markers was analyzed using multifactor dimensionality reduction (MDR) software. Power analysis was performed using the Quanto program.Results There are no significant differences in genotype or allele distribution were identified between the patients and controls (p>0.05). The haplotypes constructed by four markers rs1317286, rs6494212, rs16969968, and rs684513 were not associated with schizophrenia either. However, a significant association between models made of rs1317286, rs1044396, rs6494212, and rs684513 and schizophrenia was revealed in interaction analysis (p<0.05).Conclusion The nAChR protein may have effects on the development of schizophrenia through the interaction with proteins encoded by schizophrenia-related susceptibility genes, but no relation was found between selected polymorphisms and schizophrenia in the collected Han Chinese people. However, interaction analysis suggested four-SNP model has an important effect on schizophrenia.
#Schizophrenia #Neuronal nicotinic acetylcholine receptor #Association study #Protein-protein interaction network.

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참고문헌 (35)

참고문헌 신청
Richetto J / 2021 / Epigenetic modifications in schizophrenia and related disorders : molecular scars of environmental exposures and source of phenotypic variability / Biol Psychiatry 89:215~226 google schola Hasan A / 2020 / Schizophrenia / Dtsch Arztebl Int 117:412~419 google schola Dervaux A / 2008 / [Smoking and schizophrenia : epidemiological and clinical features] / Encephale 34:299~305 google schola Šagud M / 2018 / Smoking in schizophrenia : an updated review / Psychiatr Danub 30:216~223 google schola Kozak K / 2020 / Pharmacotherapy for smoking cessation in schizophrenia : a systematic review / Expert Opin Pharmacother 21:581~590 google schola

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