지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
이용수
초록· 키워드
오류제보하기
Tuberculosis (TB) is infectious disease caused by Mycobacterium tuberculosis (MTB) infection. It is known that not only the property of microorganism but also the genetic susceptibility of infected patients is controlled. Interleukin 2 (IL-2) is a cytokine belonging to type 1 T helper (Th1) activity. In addition, IL-2, when infected with MTB, binds IL-2 receptor and promotes T cell replication and is involved in granuloma formation. The aim of this study was to investigate the genetic polymorphisms of the IL-2 receptor gene in tuberculosis patients and normal individuals. We analyzed 22 SNPs in three genes using the genotype data of 443 tuberculosis cases and 3,228 healthy controls from the Korea Association Resource for their correlation with tuberculosis case. IL2RA, IL2RB, and IL2RG genes were genotyped of 16, 4, and 2 SNPs, respectively. Among three genes, only IL2RA gene polymorphisms showed statistically significant association with tuberculosis case. 6 SNPs with high significance were identified in the IL2RA gene. In addition, the linkage disequilibrium (LD) structure of IL2RA gene was confirmed. SNP imputation of IL2RA gene was performed, it was confirmed that more SNPs were significant between case and control. If we look at the results of IL2RA gene analysis above, we can see that genetic polymorphism in the gene expressing IL-2Rα will regulate the expression level of IL-2Rα, and the change in the immune system involved in IL-2Rα. In this study, genetic polymorphism that may affect host immunity suggests that susceptibility to tuberculosis may be controlled.
목차
서론
재료 및 방법
결과
고찰
REFERENCES
참고문헌 (23)
참고문헌 신청
[학술지(정기간행물)] - Caccamo N / 2010 / Multifunctional CD4(+) T cells correlate with active Mycobacterium tuberculosis infection / Eur J Immunol 40 : 2211 ~ 2220
[학술지(정기간행물)] - Casey R / 2010 / Enumeration of functional T-cell subsets by fluorescence-immunospot defines signatures of pathogen burden in tuberculosis / PLoS One 5 : e15619 ~
[기타자료] - Cho JE / 2014 / $RpoB_{127-135}$ Peptide Derived from Mycobacterium tuberculosis is Processed and Presented to HLAA* 0201 Restricted CD8+ T Cells via an Alternate HLA-I Processing Pathway, 20 : 250 ~ 255
[학술지(정기간행물)] - Cho YS / 2009 / A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits / Nat Genet 41 : 527 ~ 534
[학술지(정기간행물)] - Comstock GW / 1978 / Tuberculosis in twins: a re-analysis of the Prophit survey / Am Rev Respir Dis 117 : 621 ~ 624
[학술지(정기간행물)] - Casey R / 2010 / Enumeration of functional T-cell subsets by fluorescence-immunospot defines signatures of pathogen burden in tuberculosis / PLoS One 5 : e15619 ~
[기타자료] - Cho JE / 2014 /
[학술지(정기간행물)] - Cho YS / 2009 / A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits / Nat Genet 41 : 527 ~ 534
[학술지(정기간행물)] - Comstock GW / 1978 / Tuberculosis in twins: a re-analysis of the Prophit survey / Am Rev Respir Dis 117 : 621 ~ 624
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
The Allele 2 of the VNTR Polymorphism in the Gene That Encodes a Natural Inhibitor of IL-1β, IL-1RA Is Favorably Associated With Chronic Otitis Media
Clinical and Experimental Otorhinolaryngology
2018 .01
-
Association of Single Nucleotide Polymorphisms in Interleukin-12 Receptor (IL-12Rβ1 and IL-12Rβ2) with Asthma in a Korean Population
대한의생명과학회지
2020 .12
-
IL-10 Polymorphisms and Tuberculosis Susceptibility: An Updated Meta-Analysis
Yonsei Medical Journal
2015 .01
-
Association of the Genetic Polymorphisms for CD247 Gene and Tuberculosis Case
대한의생명과학회지
2020 .03
-
Association of the CD226 Genetic Polymorphisms with Risk of Tuberculosis
대한의생명과학회지
2017 .06
-
Expression of IL4Ra and IL13Rα1 in gallbladder cancer
대한임상종양학회 학술대회지
2022 .02
-
Replication Study of Association between Forkhead Box O3 (FOXO3) Polymorphisms and Tuberculosis in Korean Population
대한의생명과학회지
2020 .03
-
IL-1 Receptor Dynamics in Immune Cells: Orchestrating Immune Precision and Balance
Immune Network
2024 .06
-
Inverse behavior of IL-23R and IL-17RA in chronic and aggressive periodontitis
Journal of Periodontal & Implant Science
2021 .01
-
Enhanced Type 2 Immune Reactions by Increased IL-22/IL-22Ra1 Signaling in Chronic Rhinosinusitis With Nasal Polyps
Allergy, Asthma & Immunology Research
2020 .01
-
Interleukin-1B (IL-1B-31 and IL-1B-511) and interleukin-1 receptor antagonist (IL-1Ra) gene polymorphisms in primary immune thrombocytopenia
Blood Research
2017 .01
-
Replicated Association Study between Tuberculosis and CLCN6, DOK7, HLA-DRA in Korean
대한의생명과학회지
2020 .09
-
Association Analysis of Interleukin-1β, Interleukin-6, and HMGB1 Variants with Postictal Serum Cytokine Levels in Children with Febrile Seizure and Generalized Epilepsy with Febrile Seizure Plus
Journal of Clinical Neurology
2019 .01
-
I-Kappa-B-Zeta Regulates Interleukin-17A/Tumor Necrosis Factor-Alpha Mediated Synergistic Induction of Interleukin-19 and Interleukin-20 in Humane Keratinocytes
Annals of Dermatology
2021 .01
-
Role of IL-18 Gene Promoter Polymorphisms, Serum IL-18 Levels, and Risk of Hepatitis B Virus-related Liver Disease in the Guangxi Zhuang Population: a Retrospective Case-Control Study
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
IL-1 Receptor Antagonist Reduced Chemical-Induced Keratinocyte Apoptosis through Antagonism to IL-1α/IL-1β
Biomolecules & Therapeutics(구 응용약물학회지)
2018 .01
-
Expression of Il4rα and Il13rα1 in Gallbladder Cancer
대한외과학회 학술대회 초록집
2021 .11
-
Induction of Unique STAT Heterodimers by IL-21 Provokes IL-1RI Expression on CD8+ T Cells, Resulting in Enhanced IL-1β Dependent Effector Function
Immune Network
2021 .10
-
mRNA Expression Level of Interleukin Genes in the Determining Phases of Behçet’s Disease
Annals of Dermatology
2015 .01
-
Associations Between Circulating Interleukin-17 Levels and Systemic Lupus Erythematosus and Between Interleukin-17 Gene Polymorphisms and Disease Susceptibility: A Meta-analysis
대한류마티스학회지
2020 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0