지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.10
- 수록면
- 156 - 162 (7page)
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초록· 키워드
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Objectives：A recent study of a European sample implied that the 14 genes previously known to be related with schizophrenia may play little roles. But much work remains before dismissing these genes from their connection to schizophrenia. This is a pilot study for family based association test (FBAT) analysis of estrogen metabolism gene in a Korean population with schizophrenia.
Methods：27 probands with schizophrenia were recruited with their parents and siblings. The subjects were interviewed using Korean versions of diagnostic interview for genetic studies and family interview for genetic studies. We analyzed 2 single nucleotide polymorphism (SNP) of ESR1, COMT gene. We performed FBAT and linkage disequilibrium analyses for each individual SNP.
Results：We found a significant SNP of ESR1 gene in chromosome 6 for the qualitative phenotype of schizophrenia. That result was replicated for the quantitative phenotype of apparent onset, apparent onset of psychosis, and first treatment age. We also found a significant SNP of ESR1 gene in chromosome 6 for the quantitative phenotype of any delusions.
Conclusions：Our results show that quantitative traits such as age of onset, any delusions, and any hallucinations could be continuous with qualitative trait in schizophrenia. But we should be very cautious because there are clear limitations in some nominal number of SNPs and the small incomplete pedigrees. In the future, FBAT analyses in families with subtyped schizophrenic probands according to personality, working memory, cognition will facilitate fine mapping analyses for searching candidate genes of schizophrenia.
Methods：27 probands with schizophrenia were recruited with their parents and siblings. The subjects were interviewed using Korean versions of diagnostic interview for genetic studies and family interview for genetic studies. We analyzed 2 single nucleotide polymorphism (SNP) of ESR1, COMT gene. We performed FBAT and linkage disequilibrium analyses for each individual SNP.
Results：We found a significant SNP of ESR1 gene in chromosome 6 for the qualitative phenotype of schizophrenia. That result was replicated for the quantitative phenotype of apparent onset, apparent onset of psychosis, and first treatment age. We also found a significant SNP of ESR1 gene in chromosome 6 for the quantitative phenotype of any delusions.
Conclusions：Our results show that quantitative traits such as age of onset, any delusions, and any hallucinations could be continuous with qualitative trait in schizophrenia. But we should be very cautious because there are clear limitations in some nominal number of SNPs and the small incomplete pedigrees. In the future, FBAT analyses in families with subtyped schizophrenic probands according to personality, working memory, cognition will facilitate fine mapping analyses for searching candidate genes of schizophrenia.
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대상 및 방법
결과
고찰
참고문헌
참고문헌 (38)
참고문헌 신청
McGuffin P / 1994 / The strength of the genetic effect: is there room for an environmental influence in the aetiology of schizophrenia? / Br J Psychiatry 164:593~599
Bachmann RF / 2005 / Mood stabilizers target cellular plasticity and resilience cascades : implications for the development of novel therapeutics / Mol Neurobiol 32:173~202
Bartels SJ / 2003 / Medicare and medicaid costs for schizophrenia patients by age cohort compared with costs for depression, dementia, and medically ill patients / Am J Geriatr Psychiatry 11:648~657
Bauer M / 2002 / Bipolar disorder / Ment Health Serv Res 4:225~229
Shih RA / 2004 / A review of the evidence from family, twin and adoption studies for a genetic contribution to adult psychiatric disorders / Int Rev Psychiatry 16:260~283
Bachmann RF / 2005 / Mood stabilizers target cellular plasticity and resilience cascades : implications for the development of novel therapeutics / Mol Neurobiol 32:173~202
Bartels SJ / 2003 / Medicare and medicaid costs for schizophrenia patients by age cohort compared with costs for depression, dementia, and medically ill patients / Am J Geriatr Psychiatry 11:648~657
Bauer M / 2002 / Bipolar disorder / Ment Health Serv Res 4:225~229
Shih RA / 2004 / A review of the evidence from family, twin and adoption studies for a genetic contribution to adult psychiatric disorders / Int Rev Psychiatry 16:260~283
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