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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 1,073 - 1,078 (6page)
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Objective To investigate the association between gene polymorphism of vesicular monoamine transporter type 2(VMAT2) and schizophrenia in Han Chinese population.Methods 430 patients with schizophrenia and 470 age-sex matched controls were recruited from four mental health centers. All patients were diagnosed by two psychiatrists based on the Structured Clinical Interview for DSM Disorders (SCID). The ligase detection reactions (LDR) method was used to assess the polymorphism of the two SNPs (rs363371 and rs363324) of VMAT2.Results No associations of two SNPs with schizophrenia was found. When we stratified males and females for the analysis, we found that that in the recessive model of rs363371, there was an obvious significant association between rs363371 and schizophrenia in males (OR=0.564, 95% CI=0.357?0.892, p=0.014) but not females. For the association between rs363324 and schizophrenia, no association was found in either males or females. No association was found when stratifying early-onset schizophrenia and late-onset schizophrenia.Conclusion Our findings indicate that both rs363371 and rs363324 were not associated with schizophrenia, while it seemed that the AA genotype of rs363371 plays a protective effect in male Chinese in developing schizophrenia.
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참고문헌 (21)
참고문헌 신청
Ayhan Y / 2009 / Animal models of gene-environment interactions in schizophrenia / Behav Brain Res 204:274~281
Schizophrenia Working Group of the Psychiatric Genomics Consortium / 2014 / Biological insights from 108 schizophrenia-associated genetic loci / Nature 511:421~427
Ripke S / 2013 / Genome-wide association analysis identifies 13 new risk loci for schizophrenia / Nat Genet 45:1150~1159
Harrison PJ / 2015 / Recent genetic findings in schizophrenia and their therapeutic relevance / J Psychopharmacol 29:85~96
Williams NM / 2003 / A systematic genomewide linkage study in 353 sib pairs with schizophrenia / Am J Hum Genet 73:1355~1367
Schizophrenia Working Group of the Psychiatric Genomics Consortium / 2014 / Biological insights from 108 schizophrenia-associated genetic loci / Nature 511:421~427
Ripke S / 2013 / Genome-wide association analysis identifies 13 new risk loci for schizophrenia / Nat Genet 45:1150~1159
Harrison PJ / 2015 / Recent genetic findings in schizophrenia and their therapeutic relevance / J Psychopharmacol 29:85~96
Williams NM / 2003 / A systematic genomewide linkage study in 353 sib pairs with schizophrenia / Am J Hum Genet 73:1355~1367
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