Effects of SSRI Antidepressants on Attentional Bias toward Emotional Scenes in First-Episode Depressive Patients: Evidence from an Eye-Tracking Study

Zhang Lei; Yu Fengqiong; Hu Qian; Qiao Yuxi; Xuan Rongrong; Ji Gongjun; Zhu Chunyan; Cai Chunlan; Wang Kai

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자료유형: 학술저널

저자정보: Zhang Lei (Department of Medical Psychology Chaohu Clinical Medical College Anhui Medical University) Yu Fengqiong (Department of Medical Psychology Chaohu Clinical Medical College Anhui Medical University) Hu Qian (Department of Medical Psychology Chaohu Clinical Medical College Anhui Medical University) Qiao Yuxi (Department of Medical Psychology Chaohu Clinical Medical College Anhui Medical University) Xuan Rongrong (Department of Medical Psychology Chaohu Clinical Medical College Anhui Medical University) Ji Gongjun (Department of Medical Psychology Chaohu Clinical Medical College Anhui Medical University) Zhu Chunyan (Department of Medical Psychology Chaohu Clinical Medical College Anhui Medical University) Cai Chunlan (Anhui Mental Health Center) Wang Kai (Department of Neurology the First Affiliated Hospital of Anhui Medical University)

저널정보: 대한신경정신의학회 PSYCHIATRY INVESTIGATION PSYCHIATRY INVESTIGATION 제17권 제9호

발행연도: 2020.1

수록면: 871 - 879 (9page)

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Objective Attentional biases toward emotional scenes may represent vulnerability and maintenance factors in depression. Antidepressant therapy may improve cognitive function and reduce depression, and is considered as the mechanism of action of antidepressants. Therefore, we conducted an eye-tracking test to examine whether selective serotonin re-uptake inhibitor (SSRI) antidepressants can reduce negative attentional biases and elicit clinical responses in depression.Methods Twenty first-episode depressive patients freely viewed three types of pictures that depicted different emotional scenes (i.e., positive-control, neutral-control, and negative-control) for 4,000 ms while their eye movements were monitored. The attentional bias to different emotional scenes was assessed before and after eight weeks of SSRI treatment using the eye-tracking method. The control group included a group of healthy individuals.Results The results revealed that first-episode depressive patients oriented their gaze more frequently to negative images and less to happy images, compared to controls. Importantly, the attentional bias in depressive patients was regulated after eight weeks of SSRI treatment. Patients showed an increased tendency to fixate on positive images and a decreased tendency to focus on negative images.Conclusion This suggests that SSRI antidepressants decrease vulnerability to negative images, while having an effect on attention in respect to positive images.

#Attentional bias #Depression #SSRI #Emotion #Eye-tracking.

참고문헌 (46)

참고문헌 신청

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