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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 101 - 112 (12page)
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초록· 키워드
오류제보하기
Randomized trials have shown that selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) have better safety profiles than classical tricyclic antidepressants (TCAs). However, an increasing number of studies, including meta-analyses, naturalistic studies, and longer-term studies suggested that SSRIs and SNRIs are no less safe than TCAs. We focused on comparing the common side effects of TCAs with those of newer generation antidepressants including SSRIs, SNRIs, mirtazapine, and bupropion. The main purpose was to investigate safety profile differences among drug classes rather than the individual antidepressants, so studies containing comparison data on drug groups were prioritized. In terms of safety after overdose, the common belief on newer generation antidepressants having fewer side effects than TCAs appears to be true. TCAs were also associated with higher drop-out rates, lower tolerability, and higher cardiac side-effects. However, evidence regarding side effects including dry mouth, gastrointestinal side effects, hepatotoxicity, seizure, and weight has been inconsistent, some studies demonstrated the superiority of SSRIs and SNRIs over TCAs, while others found the opposite. Some other side effects such as sexual dysfunction, bleeding, and hyponatremia were more prominent with either SSRIs or SNRIs.
목차
등록된 정보가 없습니다.
참고문헌 (109)
참고문헌 신청
Ioannidis JP / 2008 / Effectiveness of antidepressants: an evidence myth constructed from a thousand randomized trials / Philos Ethics Humanit Med 3:14
Peretti S / 2000 / Safety and tolerability considerations: tricyclic antidepressants vs. selective serotonin reuptake inhibitors / Acta Psychiatr Scand Suppl 403:17~25
Whiskey E / 2013 / A review of the adverse effects and safety of noradrenergic antidepressants / J Psychopharmacol 27:732~739
Moret C / 2009 / Problems associated with long-term treatment with selective serotonin reuptake inhibitors / J Psychopharmacol 23:967~974
Dording CM / 2002 / The pharmacologic management of SSRI-induced side effects: a survey of psychiatrists / Ann Clin Psychiatry 14:143~147
Peretti S / 2000 / Safety and tolerability considerations: tricyclic antidepressants vs. selective serotonin reuptake inhibitors / Acta Psychiatr Scand Suppl 403:17~25
Whiskey E / 2013 / A review of the adverse effects and safety of noradrenergic antidepressants / J Psychopharmacol 27:732~739
Moret C / 2009 / Problems associated with long-term treatment with selective serotonin reuptake inhibitors / J Psychopharmacol 23:967~974
Dording CM / 2002 / The pharmacologic management of SSRI-induced side effects: a survey of psychiatrists / Ann Clin Psychiatry 14:143~147
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