Brain Imaging Study on the Pathogenesis of Depression & Therapeutic Effect of Selective Serotonin Reuptake Inhibitors

Meng Qi; Zhang Aixia; Cao Xiaohua; Sun Ning; Li Xinrong; Zhang YunQiao; Wang Yanfang

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자료유형: 학술저널

저자정보: Meng Qi (Department of Psychiatry First Hospital of Shanxi Medical University) Zhang Aixia (Department of Psychiatry First Hospital of Shanxi Medical University) Cao Xiaohua (Department of Psychiatry First Hospital of Shanxi Medical University) Sun Ning (Department of Psychiatry First Hospital of Shanxi Medical University) Li Xinrong (Department of Psychiatry First Hospital of Shanxi Medical University) Zhang YunQiao (Department of Psychiatry First Hospital of Shanxi Medical University) Wang Yanfang (Department of Psychiatry First Hospital of Shanxi Medical University)

저널정보: 대한신경정신의학회 PSYCHIATRY INVESTIGATION PSYCHIATRY INVESTIGATION 제17권 제7호

발행연도: 2020.1

수록면: 688 - 694 (7page)

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Objective Predefining the most effective treatment for patients with depressive disorders remains a problem. We will examine the differential brain regions of gray matter (GM) in major depressive disorder (MDD) patients and the relationship between changes in their volume and the efficacy of early antidepressant treatment using magnetic resonance imaging (MRI).Methods 159 never-medicated patients with first-episode MDD and 53 normal control subjects (NCs) were enrolled. The brains were scanned by MRI and measured with the 17-item Hamilton Depression Rating Scale (HAMD-17) at baseline and after 2 weeks of treatment with selective serotonin reuptake inhibitor (SSRI)s, and the non-responder group and responder group were obtained. The patients were analyzed by voxel-based morphological (VBM) and SPSS software. Receiver operator characteristics (ROC) analysis was performed for the difference between the responder group and the non-responder group in the differential brain regions, and Pearson correlations were computed between volume size and HAMD score reduction rate.Results Smaller GM volume of the right superior temporal gyrus (STG), and the orbital parts of the right medial frontal gyrus and right inferior frontal gyrus were observed in MDD versus the NCs. The non-responder group demonstrated a significant volume reduction at the right STG compared with the responders, but no corresponding change in orbital part of right medial frontal gyrus and right inferior frontal gyrus. ROC analysis showed that Accuracy=71.2%. There was a positive correlation between the STG gray matter volume and the HAMD-17 score reduction rate (r=0.347, p=0.002).Conclusion The study results confirmed the local changes in brain structure in MDD and may initially predict the early treatment response produced by SSRIs as antidepressants.

#Major depressive disorder #Voxel-based morphometry #Gray matter #Predict efficacy.

참고문헌 (32)

참고문헌 신청

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