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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제16권 제4호
- 발행연도
- 2018.1
- 수록면
- 461 - 468 (8page)
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초록· 키워드
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Objective: Cognitive disturbance is one of the major symptoms of depression and may be improved by treatment with antidepressants. This study aimed to investigate the predictors of cognitive improvement in patients with major depressive disorder (MDD) who were taking antidepressants. Methods: This study included 86 patients with MDD who completed 12 weeks of antidepressant monotherapy. Cognitive symptoms were assessed using the Perceived Deficits Questionnaire-Korean version (PDQ-K), which addresses four domains of cognitive functioning (attention/concentration, retrospective memory, prospective memory, and organization/ planning) and was administered at study entry and at the 12-week end point. A variety of demographic, clinical, and treatment-related variables were evaluated as predictors of changes in total and domain scores. Results: All PDQ-K domains showed significant improvement after 12 weeks of antidepressant treatment. More severe initial depressive symptoms, fewer sick-leave days at study entry, and reduced use of concomitant anxiolytics/hypnotics during treatment were significantly associated with greater cognitive improvement. Conclusion: Cognitive symptoms are more responsive to antidepressant treatment in patients with severe MDD. Reduced use of anxiolytics and hypnotics could improve the cognitive functioning of patients with MDD taking antidepressants.
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참고문헌 (5)
참고문헌 신청
우영섭 / 2016 / Cognitive Deficits as a Mediator of Poor Occupational Function in Remitted Major Depressive Disorder Patients / Clinical Psychopharmacology and Neuroscience 14(1):1~16
김혜금 / 2016 / Association between Cerebral Amyloid Deposition and Clinical Factors Including Cognitive Function in Geriatric Depression: Pilot Study Using Amyloid Positron Emission Tomography / Clinical Psychopharmacology and Neuroscience 14(4):378~382
Sheehan DV / 1998 / The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10 / J Clin Psychiatry 59(Suppl 20):22~33
김재민 / 2016 / Development of a Korean Version of the Perceived Deficits Questionnaire-Depression for Patients with Major Depressive Disorder / Clinical Psychopharmacology and Neuroscience 14(1):26~32
McIntyre RS / 2013 / Using measurement strategies to identify and monitor residual symptoms / J Clin Psychiatry 74(Suppl 2):14~18
김혜금 / 2016 / Association between Cerebral Amyloid Deposition and Clinical Factors Including Cognitive Function in Geriatric Depression: Pilot Study Using Amyloid Positron Emission Tomography / Clinical Psychopharmacology and Neuroscience 14(4):378~382
Sheehan DV / 1998 / The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10 / J Clin Psychiatry 59(Suppl 20):22~33
김재민 / 2016 / Development of a Korean Version of the Perceived Deficits Questionnaire-Depression for Patients with Major Depressive Disorder / Clinical Psychopharmacology and Neuroscience 14(1):26~32
McIntyre RS / 2013 / Using measurement strategies to identify and monitor residual symptoms / J Clin Psychiatry 74(Suppl 2):14~18
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