지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 440 - 446 (7page)
이용수
초록· 키워드
오류제보하기
ObjectiveaaThe aim of the present study was to investigate differences in discontinuation time among antidepressants and total antidepressant discontinuation rate of patients with depression over a 6 month period in a naturalistic treatment setting.
MethodsaaWe reviewed the medical records of 900 patients with major depressive disorder who were initially prescribed only one kind of antidepressant. The prescribed antidepressants and the reasons for discontinuation were surveyed at baseline and every 4 weeks during the 24 week study. We investigated the discontinuation rate and the mean time to discontinuation among six antidepressants groups.
ResultsaaMean and median overall discontinuation times were 13.8 and 12 weeks, respectively. Sertraline and escitalopram had longer discontinuation times than that of fluoxetine, and patients who used sertraline discontinued use significantly later than those taking mirtazapine. No differences in discontinuation rate were observed after 24 weeks among these antidepressants. About 73% of patients discontinued antidepressant treatment after 24 weeks.
ConclusionaaSertraline and escitalopram tended to have longer mean times to discontinuation, although no difference in discontinuation rate was detected between antidepressants after 24 weeks. About three-quarters of patients discontinued antidepressant maintenance therapy after 24 weeks.
목차
등록된 정보가 없습니다.
참고문헌 (35)
참고문헌 신청
Kessler RC / 2005 / Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication / Arch Gen Psychiatry 62:593~602
Kessler RC / 2003 / The epidemiology of major depressive disorder : results from the National Comorbidity Survey Replication(NCS-R) / JAMA 289:3095~3105
Wells KB / 1989 / The functioning and well-being of depressed patients. Results from the Medical Outcomes Study / JAMA 262:914~919
Murray CJ / 1996 / Evidence-based health policy--lessons from the Global Burden of Disease Study / Science 274:740~743
Greenberg PE / 1993 / The economic burden of depression in 1990 / J Clin Psychiatry 54:405~418
Kessler RC / 2003 / The epidemiology of major depressive disorder : results from the National Comorbidity Survey Replication(NCS-R) / JAMA 289:3095~3105
Wells KB / 1989 / The functioning and well-being of depressed patients. Results from the Medical Outcomes Study / JAMA 262:914~919
Murray CJ / 1996 / Evidence-based health policy--lessons from the Global Burden of Disease Study / Science 274:740~743
Greenberg PE / 1993 / The economic burden of depression in 1990 / J Clin Psychiatry 54:405~418
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