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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제25권 제7호
- 발행연도
- 2015.1
- 수록면
- 1,170 - 1,176 (7page)
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초록· 키워드
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Ginsenosides, the major active component of ginseng, are traditionally used to treat various diseases, including cancer, inflammation, and obesity. Among these, compound K (CK), an intestinal bacterial metabolite of the ginsenosides Rb1, Rb2, and Rc from Bacteroides JY-6, is reported to inhibit cancer cell growth by inducing cell-cycle arrest or cell death, including apoptosis and necrosis. However, the precise effect of CK on breast cancer cells remains unclear. MCF-7 cells were treated with CK (0-70 μM) for 24 or 48 h. Cell proliferation and death were evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and flow cytometry assays, respectively. Changes in downstream signaling molecules involved in cell death, including glycogen synthase kinase 3β (GSK3β), GSK3β, β-catenin, and cyclin D1, were analyzed by western blot assay. To block GSK3β signaling, MCF-7 cells were pretreated with GSK3β inhibitors 1 h prior to CK treatment. Cell death and the expression of β-catenin and cyclin D1 were then examined. CK dose- and time-dependently inhibited MCF-7 cell proliferation. Interestingly, CK induced programmed necrosis, but not apoptosis, via the GSK3β signaling pathway in MCF-7 cells. CK inhibited GSK3β phosphorylation, thereby suppressing the expression of β-catenin and cyclin D1. Our results suggest that CK induces programmed necrosis in MCF-7 breast cancer cells via the GSK3β signaling pathway.
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참고문헌 (23)
참고문헌 신청
Akao T / 1998 / Intestinal bacterial hydrolysis is required for the appearance of compound K in rat plasma after oral administration of ginsenoside Rb1 from Panax ginseng / J
Artus C / 2010 / AIF promotes chromatinolysis and caspase-independent programmed necrosis by interacting with histone H2AX / EMBO J 29 : 1585 ~ 1599
Bae EA / 2002 / Metabolism of ginsenoside R(c) by human intestinal bacteria and its related antiallergic activity / Biol. Pharm. Bull 25 : 743 ~ 747
Beurel E / 2006 / The paradoxical pro- and antiapoptotic actions of GSK3 in the intrinsic and extrinsic apoptosis signaling pathways / Prog. Neurobiol 79 : 173 ~ 189
Diehl JA / 1998 / Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization / Genes Dev 12 : 3499 ~ 3511
Artus C / 2010 / AIF promotes chromatinolysis and caspase-independent programmed necrosis by interacting with histone H2AX / EMBO J 29 : 1585 ~ 1599
Bae EA / 2002 / Metabolism of ginsenoside R(c) by human intestinal bacteria and its related antiallergic activity / Biol. Pharm. Bull 25 : 743 ~ 747
Beurel E / 2006 / The paradoxical pro- and antiapoptotic actions of GSK3 in the intrinsic and extrinsic apoptosis signaling pathways / Prog. Neurobiol 79 : 173 ~ 189
Diehl JA / 1998 / Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization / Genes Dev 12 : 3499 ~ 3511
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