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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.3
- 수록면
- 257 - 263 (7page)
- DOI
- 10.14348/molcells.2018.0091
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초록· 키워드
오류제보하기
Vertebrate organ development is accompanied by demarcation of tissue compartments, which grow coordinately with their neighbors. Hence, perturbing the coordinative growth of neighboring tissue compartments frequently results in organ malformation. The growth of tissue compartments is regulated by multiple intercellular and intracellular signaling pathways, including the Hippo signaling pathway that limits the growth of various organs. In the optic neuroepithelial continuum, which is partitioned into the retina, retinal pigment epithelium (RPE) and ciliary margin (CM) during eye development, the Hippo signaling activity operates differentially, as it does in many tissues. In this review, we summarize recent studies that have explored the relationship between the Hippo signaling pathway and growth of optic neuroepi-thelial compartments. We will focus particularly on the roles of a tumor suppressor, neurofibromin 2 (NF2), whose expression is not only dependent on compartment-specific transcription factors, but is also subject to regulation by a Hippo-Yap feedback signaling circuit.
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참고문헌 (77)
참고문헌 신청
Akhmametyeva, E.M. / 2006 / Regulation of the neurofibromatosis 2 gene promoter expression during embryonic development / Dev. Dyn. 235:2771~2785
Asaoka, Y. / 2014 / The Hippo pathway controls a switch between retinal progenitor cell proliferation and photoreceptor cell differentiation in zebrafish / PLoS ONE 9:e97365
Asthagiri, A.R. / 2009 / Neurofibromatosis type 2 / Lancet 373:1974~1986
Barry, E.R. / 2013 / Restriction of intestinal stem cell expansion and the regenerative response by YAP / Nature 493:106~110
Basu-Roy, U. / 2015 / Sox2 antagonizes the Hippo pathway to maintain stemness in cancer cells / Nat. Comm. 6:6411
Asaoka, Y. / 2014 / The Hippo pathway controls a switch between retinal progenitor cell proliferation and photoreceptor cell differentiation in zebrafish / PLoS ONE 9:e97365
Asthagiri, A.R. / 2009 / Neurofibromatosis type 2 / Lancet 373:1974~1986
Barry, E.R. / 2013 / Restriction of intestinal stem cell expansion and the regenerative response by YAP / Nature 493:106~110
Basu-Roy, U. / 2015 / Sox2 antagonizes the Hippo pathway to maintain stemness in cancer cells / Nat. Comm. 6:6411
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