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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 629 - 637 (9page)
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초록· 키워드
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Transient receptor potential vanilloid type 4 (TRPV4) channel is expressed in the central nervous system and its role in development of Alzheimer’s disease (AD) is largely unknown. To identify AD-related changes in the TRPV4 channel distribution in the central nervous system, we investigated the distribution and level changes of TRPV4 in brains of AD model mice. The expressions of TRPV4 in the brain of control mice, early stage and late stage AD model mice were compared using immunohistochemistry with antibodies recognizing TRPV4 on free floating sections and in addition we performed western blotting to supplement our findings. TRPV4 immunoreactivity was significantly increased in the cerebral cortex, hippocampal formation, striatum and thalamus of AD model mice compared with control mice. In the cerebral cortex, TRPV4 immunoreactivity was significantly increased in pyramidal cells of early stage and late stage AD model mice. In addition, TRPV4 immunoreactivity was increased in the hippocampal formation, striatum and thalamus of late stage AD model mice. This is the first demonstration of AD-related increases in TRPV4 expression in the brain and it may provide useful data for investigating the pathogenesis of AD-related neurodegenerative diseases. The regulation of TRPV4 in AD mouse model and its functional significance require further investigation.
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참고문헌 (43)
참고문헌 신청
Alessandri-Haber N / 2003 / Hypotonicity induces TRPV4-mediated nociception in rat / Neuron 39:497~511
Baglietto-Vargas D / 2010 / Calretinin interneurons are early targets of extracellular amyloid-beta pathology in PS1/AbetaPP Alzheimer mice hippocampus / J Alzheimers Dis 21:119~132
Benham CD / 2002 / Vanilloid and TRP channels: a family of lipid-gated cation channels / Neuropharmacology 42:873~888
Berridge MJ / 2000 / The versatility and universality of calcium signaling / Nat Rev Mol Cell Biol 1:11~21
Butenko O / 2012 / The increased activity of TRPV4 channel in the astrocytes of the adult rat hippocampus after cerebral hypoxia/ischemia / PLoS One 7:39959
Baglietto-Vargas D / 2010 / Calretinin interneurons are early targets of extracellular amyloid-beta pathology in PS1/AbetaPP Alzheimer mice hippocampus / J Alzheimers Dis 21:119~132
Benham CD / 2002 / Vanilloid and TRP channels: a family of lipid-gated cation channels / Neuropharmacology 42:873~888
Berridge MJ / 2000 / The versatility and universality of calcium signaling / Nat Rev Mol Cell Biol 1:11~21
Butenko O / 2012 / The increased activity of TRPV4 channel in the astrocytes of the adult rat hippocampus after cerebral hypoxia/ischemia / PLoS One 7:39959
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