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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.8
- 수록면
- 201 - 210 (10page)
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Allergic inflammation requires the orchestration of altered gene expression in the target tissue and in the infiltrating immune cells. The transcription factor STAT6 is critical in activating cytokine gene expression and cytokine signaling both in the immune cells and in target tissue cells including airway epithelia, keratinocytes and esophageal epithelial cells. STAT6 is activated by the cytokines IL-4 and IL-13 to mediate the pathogenesis of allergic disorders such as asthma, atopic dermatitis, food allergy and eosinophilic esophagitis (EoE). In this review, we summarize the role of STAT6 in allergic diseases, its interaction with the co-factor PARP14 and the molecular mechanisms by which STAT6 and PARP14 regulate gene transcription.
목차
INTRODUCTION
STAT6
MECHANISMS OF STAT6-DEPENDENT GENE REGULATION
CONCLUDING REMARKS
REFERENCES
참고문헌 (83)
참고문헌 신청
[학술지(정기간행물)] - Levy, D. E / 2002 / Stats: transcriptional control and biological impact / Nat. Rev. Mol. Cell Biol 3 : 651 ~ 662
[학술지(정기간행물)] - Galli, S. J / 2008 / The development of allergic inflammation / Nature 454 : 445 ~ 454
[학술지(정기간행물)] - Quelle, F. W / 1995 / Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosphorylated in responses to IL-4 and IL-3 but are not required for mitogenesis / Mol. Cell. Biol 15 : 3336 ~ 3343
[학술지(정기간행물)] - Mikita, T / 1996 / Requirements for interleukin-4-induced gene expression and functional characterization of Stat6 / Mol. Cell. Biol 16 : 5811 ~ 5820
[학술지(정기간행물)] - Wurster, A. L / 2000 / The biology of Stat4 and Stat6 / Oncogene 19 : 2577 ~ 2584
[학술지(정기간행물)] - Galli, S. J / 2008 / The development of allergic inflammation / Nature 454 : 445 ~ 454
[학술지(정기간행물)] - Quelle, F. W / 1995 / Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosphorylated in responses to IL-4 and IL-3 but are not required for mitogenesis / Mol. Cell. Biol 15 : 3336 ~ 3343
[학술지(정기간행물)] - Mikita, T / 1996 / Requirements for interleukin-4-induced gene expression and functional characterization of Stat6 / Mol. Cell. Biol 16 : 5811 ~ 5820
[학술지(정기간행물)] - Wurster, A. L / 2000 / The biology of Stat4 and Stat6 / Oncogene 19 : 2577 ~ 2584
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UCI(KEPA) : I410-ECN-0101-2017-517-000981441