지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.6
- 수록면
- 180 - 181 (2page)
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초록· 키워드
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Background/Aims
Genomic instability is characterized by multiple features and is regarded as an important predictor of chemotherapy and immunotherapy responses in cancer treatment. However, most studies on gastric cancers have only focused on a single aspect of genomic instability. Genomic instability-associated lncRNAs have been reported to exert a profound impact on multiple cancers, but research on their effects on gastric cancers is insufficient. The role of UBQLN4, as a newly emerging protein representing the genomic stability state, in GC is still obscure. The aim of our study was to identify a genomic instability-associated lncRNA signature to help predict the survival and chemotherapy response of GCs and assess whether UBQLN4 expression variation can be used for a similar function. Further in-depth study based on multiplexed immunohistochemical staining also helped reveal the immune landscape change based on the variations reflected by both the lncRNA signature and UBQLN4 expression.
Methods
RNA sequencing and somatic mutation variation (SNV) data from patients with gastric cancer obtained from TCGA datasets were used to explore genomic instability-associated lncRNAs. First, SNV data from all the patients was rearranged in order of decreasing number of cumulative somatic mutations. The top one-quarter of patients were defined as the genomically stable group, while the bottom one-quarter were defined as the genomically unstable group. Differentially expressed lncRNAs with a threshold of |log2 FC | > 1 and P-value < 0.05 between the two groups were defined as genomic instability-associated lncRNAs. Lasso and Cox regression analysis of the selected lncRNAs was performed to establish a genomic instability-associated lncRNA signature. Analysis of immune-associated and chemotherapy responses was further conducted to determine the predictive value of the lncRNA signature. A tissue microarray composed of tissues from 147 patients with gastric from Zhongshan Hospital was used to conduct IHC for UBQLN4. Clinical characteristics were also analysed based the ... 전체 초록 보기
Genomic instability is characterized by multiple features and is regarded as an important predictor of chemotherapy and immunotherapy responses in cancer treatment. However, most studies on gastric cancers have only focused on a single aspect of genomic instability. Genomic instability-associated lncRNAs have been reported to exert a profound impact on multiple cancers, but research on their effects on gastric cancers is insufficient. The role of UBQLN4, as a newly emerging protein representing the genomic stability state, in GC is still obscure. The aim of our study was to identify a genomic instability-associated lncRNA signature to help predict the survival and chemotherapy response of GCs and assess whether UBQLN4 expression variation can be used for a similar function. Further in-depth study based on multiplexed immunohistochemical staining also helped reveal the immune landscape change based on the variations reflected by both the lncRNA signature and UBQLN4 expression.
Methods
RNA sequencing and somatic mutation variation (SNV) data from patients with gastric cancer obtained from TCGA datasets were used to explore genomic instability-associated lncRNAs. First, SNV data from all the patients was rearranged in order of decreasing number of cumulative somatic mutations. The top one-quarter of patients were defined as the genomically stable group, while the bottom one-quarter were defined as the genomically unstable group. Differentially expressed lncRNAs with a threshold of |log2 FC | > 1 and P-value < 0.05 between the two groups were defined as genomic instability-associated lncRNAs. Lasso and Cox regression analysis of the selected lncRNAs was performed to establish a genomic instability-associated lncRNA signature. Analysis of immune-associated and chemotherapy responses was further conducted to determine the predictive value of the lncRNA signature. A tissue microarray composed of tissues from 147 patients with gastric from Zhongshan Hospital was used to conduct IHC for UBQLN4. Clinical characteristics were also analysed based the ... 전체 초록 보기
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UCI(KEPA) : I410-ECN-0101-2021-514-001919561