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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 1 - 17 (17page)
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Objective: Cervical cancer is one of the most common malignant tumors. Our previous results showed that long non-coding RNA (lncRNA) XLOC_006390 plays an important role in cervical cancer. In this study, we have explored the mechanism of action of lncRNA XLOC_006390. Methods: LncRNA XLOC_006390 was proposed to exercise its function as a competing endogenous RNA (ceRNA), and its potential targeted miRNAs was predicted through the database LncBase Predicted v.2. Two miRNAs, miR-331-3p, and miR-338-3p, were chosen for the study. Expression of miRNAs and lncRNA in cervical cancer cells and tissues was detected by reverse transcription polymerase chain reaction. To determine the correlation, silencing of XLOC_006390, over-expression of miR-331-3p, and miR-338-3p was performed in SiHa and Caski cell lines, respectively. Results: Based on the interactive effect between miRNA and lncRNA, miR-331-3p and miR-338-3p were significantly downregulated in cervical cancer cells and tissues, and their expression levels were negatively related to that of lncRNA. Our results also showed that the expression of miR-331-3p target gene NRP2, miR-338-3p target genes PKM2, EYA2 was significantly downregulated when the XLOC_006390 was knocked down. Further, XLOC_006390 was found to facilitate cervical cancer tumorigenesis and metastasis by downregulating miR-331-3p and miR-338-3p expression. Conclusion: Taken together, our study demonstrated that XLOC_006390 may serve as a ceRNA and reversely regulates the expression of miR-331-3p and miR-338-3p, thus facilitating cervical cancer tumorigenesis and metastasis.
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참고문헌 (49)
참고문헌 신청
Marth C / 2017 / Cervical cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up / Ann Oncol 28:iv72~iv83
Global Burden of Disease Cancer Collaboration / 2017 / Global, regional, and national cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life-years for 32 cancer groups, 1990 to 2015: a systematic analysis for the global burden of disease study / JAMA Oncol 3:524~548
Zhu H / 2016 / Molecular mechanisms of cisplatin resistance in cervical cancer / Drug Des Devel Ther 10:1885~1895
Kartha RV / 2014 / Competing endogenous RNAs (ceRNAs): new entrants to the intricacies of gene regulation / Front Genet 5:8
Fang Y / 2016 / Roles, functions, and mechanisms of long non-coding RNAs in cancer / Genomics Proteomics Bioinformatics 14:42~54
Global Burden of Disease Cancer Collaboration / 2017 / Global, regional, and national cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life-years for 32 cancer groups, 1990 to 2015: a systematic analysis for the global burden of disease study / JAMA Oncol 3:524~548
Zhu H / 2016 / Molecular mechanisms of cisplatin resistance in cervical cancer / Drug Des Devel Ther 10:1885~1895
Kartha RV / 2014 / Competing endogenous RNAs (ceRNAs): new entrants to the intricacies of gene regulation / Front Genet 5:8
Fang Y / 2016 / Roles, functions, and mechanisms of long non-coding RNAs in cancer / Genomics Proteomics Bioinformatics 14:42~54
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