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논문 기본 정보

자료유형
학술저널
저자정보
Pan, Jing-Jing (Clinical Laboratory, the First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University) Xie, Xiao-Juan (Clinical Laboratory, the First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University) Li, Xu (Translational Medicine Center, the First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University) Chen, Wei (Clinical Laboratory, the First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University)
저널정보
아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제16권 제18호
발행연도
2015.1
수록면
8,067 - 8,073 (7page)

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Background: Long non-coding RNAs (lncRNAs) are emerging as key players in gene expression that govern cell developmental processes, and thus contributing to diseases, especially cancers. Many studies have suggested that aberrant expression of lncRNAs is responsible for drug resistance, a substantial obstacle for cancer therapy. Drug resistance not only results from individual variations in patients, but also from genetic and epigenetic differences in tumors. It is reported that drug resistance is tightly modulated by lncRNAs which change the stability and translation of mRNAs encoding factors involved in cell survival, proliferation, and drug metabolism. In this review, we summarize recent advances in research on lncRNAs associated with drug resistance and underlying molecular or cellular mechanisms, which may contribute helpful approaches for the development of new therapeutic strategies to overcome treatment failure.

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