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Evaluation of cytotoxicity and inflammatory tissue response of mineral trioxide aggregates containing dicalcium phosphate dihydrate
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Dicalcium phosphate dihydrate가 포함된 mineral trioxide aggregates의 세포독성 및 조직염증반응

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Type
Academic journal
Author
Hyun Jae Park (서울대학교) Hee Chul Park (서울대학교) Gitae Son (서울대학교) Yongjoon Kim (서울대학교) Lele Wu (서울대학교) Sang Hoon Choi (서울대학교) Hyeong-Cheol Yang (서울대학교)
Journal
Korean Society for Dental Materials Korean Journal of Dental Materials Vol.48 No.2(Wn.130) KCI Accredited Journals
Published
2021.6
Pages
125 - 134 (10page)
DOI
10.14815/kjdm.2021.48.2.125

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Evaluation of cytotoxicity and inflammatory tissue response of mineral trioxide aggregates containing dicalcium phosphate dihydrate
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The purpose of this study was to evaluate the effect of dicalcium phosphate dihydrate (DCPD) on the biocompatibility of mineral trioxide aggregate (MTA). DCPD was added to MTA (OrthoMTA) to suppress the increase in pH of MTA during hardening, and the change of pH, cytotoxicity, and subcutaneous inflammation reactions in mouse model were observed. The pH of OrthoMTA and DCPD-OrthoMTA at 1st day in phosphate-buffered saline was 12.5 and 12.8, respectively. At 19th day, the pH was 11.6 (OrthoMTA) and 8.8 (DCPD-OrthoMTA). Cytotoxicity of DCPD-OrthoMTA extract was lesser than that of OrthoMTA at high concentration (above 50%) (p<0.05). No significant differences appeared in subcutaneous inflammatory reactions among ProRoot MTA, OrthoMTA and DCPD-OrthoMTA. Therefore, it is likely that there is no apparent relationship between the cytotoxicity and subcutaneous inflammation in our experimental conditions.
#Mineral trioxide aggregates #Dicalcium phosphate dihydrate #Cytotoxicity #Subcutaneous inflammation #세포독성 #피하염증

Contents

서론
재료 및 방법
결과
고찰
결론
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References (25)

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Lee SJ / 1993 / Sealing ability of a mineral trioxide aggregate for repair of lateral root perforations / J Endod 19(11):541~544 google schola Bates CF / 1996 / Longitudinal sealing ability of mineral trioxide aggregate as a root-end filling material / J Endod 22(11):575~578 google schola Andelin WE / 2002 / Microleakage of resected MTA / J Endod 28(8):573~574 google schola Al-Kahtani A / 2005 / In-vitro evaluation of microleakage of an orthograde apical plug of mineral trioxide aggregate in permanent teeth with simulated immature apices / J Endod 31(2):117~119 google schola Rahimi S / 2008 / Comparison of microleakage with three different thicknesses of mineral trioxide aggregate as root-end filling material / J Oral Sci 50(3):273~277 google schola

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