지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.9
- 수록면
- 192 - 200 (9page)
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초록· 키워드
오류제보하기
Natural products have received revived interest via traditional remedies or alternative medicine used for the treatment of various diseases. Zanthoxylum piperitum (ZP) has been utilized in traditional medicine for various medicinal purposes. The present study was conducted to evaluate whether ZP modulates allergic inflammation both in vivo and in vitro. We examined the pharmacological effects of ZP on 2, 4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD) symptoms in mice. Additionally, in order to clarify the anti-inflammatory mechanisms of ZP, we elucidate the effect of ZP on the expression levels of inflammatory cytokines and nuclear factor-κB (NF-κB) in phorbol 12-myristate 13-acetate plus calcium ionophore A23187 (PMACI)-stimulated human mast cells (HMC-1). The results demonstrated that ZP attenuated AD clinical symptoms such as erythema, edema and dryness as well as histamine and IgE serum levels in DNCB-induced AD model mice. Additionally, ZP suppressed the expression of inflammatory cytokines and activation of NF-κB in AD-like skin lesions and stimulated HMC-1. These results provide experimental evidence that ZP may be useful candidate for treating allergic inflammation including AD.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (25)
참고문헌 신청
Berke R / 2012 / Atopic dermatitis : an overview / American Family Physician 86:35~42
Birrell MA / 2005 / Ikappa-B kinase-2 inhibitor blocks inflammation in human airway smooth muscle and a rat model of asthma / American Journal of Respiratory and Critical Care Medicine 172:962~971
Chan CC / 2013 / Effect of dehydroepiandrosterone on atopic dermatitis-like skin lesions induced by 1-chloro-2, 4-dinitrobenzene in mouse / Journal of Dermatological Science 72:149~157
Soo-Im Choi / 2008 / Antibacterial Activity of Essential Oils from Zanthoxylum piperitum A.P.DC. and Zanthoxylum schinifolium / Food Science and Biotechnology 17(1):195~198
Das A / 2017 / Use of Topical Corticosteroids in Dermatology : An Evidence-based Approach / Indian Journal of Dermatology 62:237~250
Birrell MA / 2005 / Ikappa-B kinase-2 inhibitor blocks inflammation in human airway smooth muscle and a rat model of asthma / American Journal of Respiratory and Critical Care Medicine 172:962~971
Chan CC / 2013 / Effect of dehydroepiandrosterone on atopic dermatitis-like skin lesions induced by 1-chloro-2, 4-dinitrobenzene in mouse / Journal of Dermatological Science 72:149~157
Soo-Im Choi / 2008 / Antibacterial Activity of Essential Oils from Zanthoxylum piperitum A.P.DC. and Zanthoxylum schinifolium / Food Science and Biotechnology 17(1):195~198
Das A / 2017 / Use of Topical Corticosteroids in Dermatology : An Evidence-based Approach / Indian Journal of Dermatology 62:237~250
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UCI(KEPA) : I410-ECN-0101-2020-510-001306006