지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 7 - 12 (6page)
이용수
초록· 키워드
오류제보하기
Laboratory animal models have been developed to investigate preventive or therapeutic effect of medicinal products, or occurrence or progression mechanism of atopic dermatitis (AD), a pruritic and persistent inflammatory skin disease. The murine model with immunologic phenomena resembling human AD was introduced, which demonstrated skewedness toward predominance of type-2 helper T cell reactivity and pathophysiological changes similar as human AD following 2,4-dinitrochlorobenzene (DNCB) sensitization and challenge. Molecular mechanism on the DNCB-mediated AD was further evaluated. Skin tissues were collected from mice treated with DNCB, and each tissue was equally divided into two sections; one for protein and the other for mRNA analysis. Expression of filaggrin, an important protein for keratinocyte integrity, was evaluated through SDS-PAGE. Level of mRNA expression for cytokines was determined through semi-quantitative reverse transcriptase polymerase chain reaction. Expression of filaggrin protein was significantly enhanced in the mice treated with DNCB compared with the vehicle (acetone : olive oil = 4 : 1 mixture) treatment group or the normal group without any treatment. Level of tumor necrosis factor-alpha and interleukin-18 mRNA expression, cytokines involved in activity of type-1 helper T (TH1) cell, was significantly downregulated in the AD group compared with other control groups. These results suggest that suppression of TH1 cell-mediated immune response could be reflected into the skin tissue of mice treated with DNCB for AD induction, and disturbance of keratinocyte integrity might evoke a compensatory mechanism.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (36)
참고문헌 신청
Weidinger, S. / 2016 / Atopic dermatitis / Lancet 387:1109~1122
Deckers, I.A. / 2012 / Investigating international time trends in the incidence and prevalence of atopic eczema 1990-2010: a systematic review of epidemiological studies / PLoS ONE 7:e39803
Egawa, G. / 2015 / Pathogenesis of atopic dermatitis: a short review / Cogent Biol. 1:1103459
Hensel, P. / 2015 / Canine atopic dermatitis: detailed guidelines for diagnosis and allergen identification / BMC Vet. Res. 11:196
Matsumoto, M. / 1999 / IgE hyperproduction through enhanced tyrosine phosphorylation of Janus kinase 3 in NC/Nga mice, a model for human atopic dermatitis / J. Immunol. 162:1056~1063
Deckers, I.A. / 2012 / Investigating international time trends in the incidence and prevalence of atopic eczema 1990-2010: a systematic review of epidemiological studies / PLoS ONE 7:e39803
Egawa, G. / 2015 / Pathogenesis of atopic dermatitis: a short review / Cogent Biol. 1:1103459
Hensel, P. / 2015 / Canine atopic dermatitis: detailed guidelines for diagnosis and allergen identification / BMC Vet. Res. 11:196
Matsumoto, M. / 1999 / IgE hyperproduction through enhanced tyrosine phosphorylation of Janus kinase 3 in NC/Nga mice, a model for human atopic dermatitis / J. Immunol. 162:1056~1063
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UCI(KEPA) : I410-ECN-0101-2018-513-001743687