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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.3
- 수록면
- 38 - 45 (8page)
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초록· 키워드
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Black-red ginseng (BRGP) exhibits more potent biological activities than white and red ginseng. However, the effect of BRGP on allergic inflammation has not been studied extensively. In this study, we attempted to evaluate the effects of BRGP on allergic inflammation in vitro and in vivo. The effects of BRGP on pro-inflammatory mediators in phorbol myristate acetate (PMA) and A23187-stimulated human mast cells (HMC-1) and on trimellitic anhydride (TMA)-induced atopic dermatitis-like skin lesions in BALB/c mice were evaluated. BRGP suppressed the expression of TNF-α, IL-6 and IL-8 from HMC-1 stimulated with PMA and A23187. Furthermore, the oral administration of BRGP markedly significantly reduced apparent severity of atopic dermatitis-like skin lesions, ear swelling, lymph node weight gains and serum IgE levels induced by TMA in mice. BRGP treatment also ameliorated epidermal hyperplasia and infiltration of inflammatory cells including mast cells. Taken together, BRGP possesses significant anti-atopic efficacy, suggesting that it could be used as a potential therapeutic agent for allergic inflammatory diseases, including atopic dermatitis.
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참고문헌 (22)
참고문헌 신청
Pawankar, R. / 2012 / Allergic diseases and asthma: a major global health concern / Curr. Opin. Allergy Clin. Immunol 12:39~41
Choi, W. J. / 2012 / Prevalence and risk factors for atopic dermatitis: a cross-sectional study of 6,453 Korean preschool children / Acta Derm. Venereol 92:467~471
Hassan, A. S. / 2007 / Clinical and immunopathologic findings during treatment of recalcitrant atopic eczema with efalizumab / J. Am. Acad. Dermatol 56:217~221
Holm, J. G. / 2016 / Quality of life and disease severity in patients with atopic dermatitis / J. Eur. Acad. Dermatol. Venereol 30:1760~1767
Leung, D. Y. / 1997 / Disease management of atopic dermatitis: a practice parameter. Joint task force on practice parameters, representing the american academy of allergy, asthma and immunology, the american college of allergy, asthma and immunology and the joint council of allergy, asthma and immunology. Work group on atopic dermatitis / Ann. Allergy. Asthma. Immunol 79:197~211
Choi, W. J. / 2012 / Prevalence and risk factors for atopic dermatitis: a cross-sectional study of 6,453 Korean preschool children / Acta Derm. Venereol 92:467~471
Hassan, A. S. / 2007 / Clinical and immunopathologic findings during treatment of recalcitrant atopic eczema with efalizumab / J. Am. Acad. Dermatol 56:217~221
Holm, J. G. / 2016 / Quality of life and disease severity in patients with atopic dermatitis / J. Eur. Acad. Dermatol. Venereol 30:1760~1767
Leung, D. Y. / 1997 / Disease management of atopic dermatitis: a practice parameter. Joint task force on practice parameters, representing the american academy of allergy, asthma and immunology, the american college of allergy, asthma and immunology and the joint council of allergy, asthma and immunology. Work group on atopic dermatitis / Ann. Allergy. Asthma. Immunol 79:197~211
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