지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.12
- 수록면
- 303 - 309 (7page)
이용수
초록· 키워드
오류제보하기
β-sitosterol, one of phytosterols, exhibited numerous pharmacological effect including anti-inflammatory, anti-cancer and immune-modulating properties. This study attempted to determine the pharmacological effects of β-sitosterol on atopic dermatitis (AD). We investigated to ascertain the pharmacological effects of β-sitosterol on 2, 4-dinitrochlrobenzene (DNCB)-induced AD symptom and histamine-induced scratching behaviors in mice. Additionally, we evaluated the effects of β-sitosterol on the interleukin (IL)-6 levels in HaCaT cells and skin tissue of AD. The findings of this study demonstrated that β-sitosterol reduced AD clinical symptoms such as eczematous, erythema and dryness and serum histamine and IgE levels in DNCB-induced AD model and histamine-induced scratching behaviors in mice. Additionally, β-sitosterol inhibited the IL-6 expression in AD-like skin lesion and HaCaT cells. Collectively, these findings provide that β-sitosterol could be a therapeutic agent for skin inflammation including AD.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (22)
참고문헌 신청
Allam JP, Novak N. The pathophysiology of atopic eczema. Clinical and Experimental Dermatology. 2006. 31: 89-93.
Bieber T. Atopic dermatitis. New England Journal of Medicine. 2008. 358: 1483-1494.
Berke R, Singh A, Guralnick M. Atopic dermatitis: an overview. American Family Physician. 2012. 86: 35-42.
Brenninkmeijer EE, Spuls PI, Legierse CM, Lindeboom R, Smitt JH, Bos JD. Clinical differences between atopic and atopiform dermatitis. Journal of the American Academy of Dermatology. 2008. 58: 407-414.
Buske-Kirschbaum A, Geiben A, Hellhammer D. Psychobiological aspects of atopic dermatitis: an overview. Psychotherapy and Psychosomatics. 2001. 70: 6-16.
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UCI(KEPA) : I410-ECN-0101-2018-510-001723186