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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 496 - 507 (12page)
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초록· 키워드
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Background: Recent epidemiological studies have demonstrated that air pollution is associated with the inflammatory response and may aggravate inflammatory skin diseases such as atopic dermatitis (AD). However, it is unclear whether particulate matter (PM) aggravates AD symptoms. Objective: The aim of this study was to investigate whether PM exposure affects the skin barrier dysfunction and aggravates AD symptoms using human keratinocytes (HaCaT) cells and a mouse model of oxazolone-induced AD-like skin. Methods: Standard reference material (SRM) 1649b, which mainly comprises polycyclic aromatic hydrocarbons, was used as the reference PM. HaCaT cells and mouse model of oxazolone-induced AD-like skin were treated with PM. The mRNA or protein expression levels of stratum corneum (SC) and tight junction (TJ) proteins, inflammatory cytokines, as well as clinical and histological changes of the AD-like skin of mouse model were evaluated. The expression of genes and proteins was analyzed by real-time polymerase chain reaction and Western blotting. Levels of inflammatory cytokines were measured by enzyme-linked immunosorbent assay. Results: The results revealed that PM downregulates the expression levels of several SC and TJ-related proteins in the mouse model with AD-like skin. Clinically, epidermal and dermal thickness was significantly increased and dermal inflammation was prominent in PM treated AD-like skin. Conclusion: In conclusion, we found that PM aggravates skin barrier dysfunction, clinically augmenting epidermal and dermal thickening with dermal inflammation in AD-like skin. These results suggest that PM may trigger the exacerbation of AD symptoms via skin barrier dysfunction-related mechanisms.
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참고문헌 (47)
참고문헌 신청
Kim KE / 2016 / Air pollution and skin diseases : adverse effects of airborne particulate matter on various skin diseases / Life Sci 152:126~134
Lee CW / 2016 / Eupafolin ameliorates COX-2 expression and PGE2production in particulate pollutants-exposed human keratinocytes through ROS/MAPKs pathways / J Ethnopharmacol 189:300~309
Pan TL / 2015 / The impact of urban particulate pollution on skin barrier function and the subsequent drug absorption / J Dermatol Sci 78:51~60
Kappos AD / 2004 / Health effects of particles in ambient air / Int J Hyg Environ Health 207:399~407
Anderson JO / 2012 / Clearing the air : a review of the effects of particulate matter air pollution on human health / J Med Toxicol 8:166~175
Lee CW / 2016 / Eupafolin ameliorates COX-2 expression and PGE2production in particulate pollutants-exposed human keratinocytes through ROS/MAPKs pathways / J Ethnopharmacol 189:300~309
Pan TL / 2015 / The impact of urban particulate pollution on skin barrier function and the subsequent drug absorption / J Dermatol Sci 78:51~60
Kappos AD / 2004 / Health effects of particles in ambient air / Int J Hyg Environ Health 207:399~407
Anderson JO / 2012 / Clearing the air : a review of the effects of particulate matter air pollution on human health / J Med Toxicol 8:166~175
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