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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 917 - 925 (9page)
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초록· 키워드
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Whey protein, a by-product of milk curdling, exhibits diverse biological activities and is used as a dietary supplement. However, its effects on stress-induced vascular aging have not yet been elucidated. In this study, we found that whey protein significantly inhibited the Ang II-primed premature senescence of vascular smooth muscle cells (VSMCs). In addition, we observed a marked dose- and time-dependent increase in SIRT1 promoter activity and mRNA in VSMCs exposed to whey protein, accompanied by elevated SIRT1 protein expression. Ang II-mediated repression of SIRT1 level was dose-dependently reversed in VSMCs treated with whey protein, suggesting that SIRT1 is involved in preventing senescence in response to this treatment. Furthermore, resveratrol, a well-defined activator of SIRT1, potentiated the effects of whey protein on Ang II-primed premature senescence, whereas sirtinol, an inhibitor of SIRT1, exerted the opposite. Taken together, these results indicated that whey protein-mediated upregulation of SIRT1 exerts an anti-senescence effect, and can thus ameliorate Ang II-induced vascular aging as a dietary supplement.
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참고문헌 (36)
참고문헌 신청
Brunet, A. / 2004 / Stressdependent regulation of FOXO transcription factors by the SIRT1 deacetylase / Science 303:2011~2015
Chen, H. Z. / 2016 / Age-associated sirtuin 1 reduction in vascular smooth muscle links vascular senescence and inflammation to abdominal aortic aneurysm / Circ. Res 119:1076~1088
Chen, W. Y. / 2005 / Tumor suppressor HIC1 directly regulates SIRT1to modulate p53-dependent DNA-damage responses / Cell 123:437~448
Cohen, H. Y. / 2004 / Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase / Science 305:390~392
Da Silva, M. S. / 2017 / Whey protein hydrolysate and branched-chain amino acids downregulate inflammation-related genes in vascular endothelial cells / Nutr. Res 38:43~51
Chen, H. Z. / 2016 / Age-associated sirtuin 1 reduction in vascular smooth muscle links vascular senescence and inflammation to abdominal aortic aneurysm / Circ. Res 119:1076~1088
Chen, W. Y. / 2005 / Tumor suppressor HIC1 directly regulates SIRT1to modulate p53-dependent DNA-damage responses / Cell 123:437~448
Cohen, H. Y. / 2004 / Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase / Science 305:390~392
Da Silva, M. S. / 2017 / Whey protein hydrolysate and branched-chain amino acids downregulate inflammation-related genes in vascular endothelial cells / Nutr. Res 38:43~51
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