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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 106 - 117 (12page)
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초록· 키워드
오류제보하기
Cellular senescence is associated with age-related vascular disorders and has been implicated in vascular dysfunctions. Here, we show that duck oil-loaded nanoemulsion (DO-NE) attenuates premature senescence of vascular smooth muscle cells (VSMCs) triggered by angiotensin II (Ang II). Compared with control nanoemulsion (NE), DO-NE significantly inhibited the activity of senescence-associated β-galactosidase, which is a biomarker of cellular senescence, in Ang II-treated VSMCs. SIRT1 protein expression was dose- and time-dependently induced in VSMCs exposed to DO-NE, but not in those exposed to NE, and SIRT1 promoter activity was also elevated. Consistently, DO-NE also dose-dependently rescued Ang II-induced repression of SIRT1 expression, indicating that SIRT1 is linked to the anti-senescence action of DO-NE in VSMCs treated with Ang II. Furthermore, the SIRT1 agonist resveratrol potentiated the effects of DO-NE on VSMCs exposed to Ang II, whereas the SIRT1 inhibitor sirtinol elicited the opposite effect. These findings indicate that DO-NE inhibits senescence by upregulating SIRT1 and thereby impedes vascular aging triggered by Ang II.
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등록된 정보가 없습니다.
참고문헌 (42)
참고문헌 신청
Bennett DC / 2008 / Comparison of the antioxidant properties of emu oil with other avian oils / Aust J Exp Agric 48:1345~1350
Brunet A / 2004 / Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase / Science 303:2011~2015
Chen HZ / 2016 / Age-associated sirtuin 1 reduction in vascular smooth muscle links vascular senescence and inflammation to abdominal aortic aneurysm / Circ Res 119:1076~1088
Chen WY / 2005 / Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses / Cell 123:437~448
Cohen HY / 2004 / Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase / Science 305:390~392
Brunet A / 2004 / Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase / Science 303:2011~2015
Chen HZ / 2016 / Age-associated sirtuin 1 reduction in vascular smooth muscle links vascular senescence and inflammation to abdominal aortic aneurysm / Circ Res 119:1076~1088
Chen WY / 2005 / Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses / Cell 123:437~448
Cohen HY / 2004 / Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase / Science 305:390~392
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