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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 259 - 272 (14page)
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초록· 키워드
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This study aims to investigate the protective effects of kefir against myocardial infarction induced by isoproterenol (ISO). The rats were randomly divided into 4 groups, each group consisting of 8 rats. The control group, the kefir group (5 mL/kg/d kefir administered to rats as intra-gastric gavage for 60 d), the ISO group (100 mg/kg ISO was administered to rats, s.c. on 61. and 62. d), and kefir+ISO group (5 mL/kg/d kefir was administered to rats intra gastric gavage for 60 days prior to ISO, 100 mg/kg in two doses on day 61 and 62). 12 h after the last ISO dose, all rats were decapitated and their blood samples were collected. Cardiac tissue was reserved for histopathological examination. creatine kinase (CK), alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), triglycerides, total cholesterol,very low density lipoprotein (VLDL), low density lipoprotein (LDL), high density lipoprotein (HDL) and glucose were measured by autoanalyzer, whole blood malondialdehyde (MDA), glutathione (GSH) and plasma advanced oxidation protein products (AOPP) levels were measured spectrophotometrically. It was determined that in the group of kefir+ISO, the levels of AST (p<0.001), CK (p<0.001), LDH (p<0.001), MDA (p<0.001) and AOPP (p<0.001) were decreased, while the GSH (p<0.05) increased, compared to ISO group. There were no significant changes in lipid profile and glucose levels between these two groups. In conclusion, by examining cardiac enzymes and histopathological changes in cardiac tissue, it can be concluded that the administration of kefir in myocardial infarction induced by ISO can protect the heart with its antioxidant characteristic and minimize the toxic damage created by ISO.
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등록된 정보가 없습니다.
참고문헌 (80)
참고문헌 신청
Abbas AM / 2016 / Cardioprotective effect of resveratrol analogue isorhapontigenin versus omega-3 fatty acids in isoproterenol-induced myocardial infarction in rats / J Physiol Biochem 72:469~484
Ahmed SM / 2017 / Efficacy of gold nanoparticles against isoproterenol induced acute myocardial infarction in adult male albino rats / Ultrastruct Pathol 41:168~185
Al-Hadi HA / 2009 / Cardiac marcers in the early diagnosis and management of patients with acute coronary syndrome / Sultan Qaboos Univ Med J 9:231~246
Alam MN / 2017 / Astaxanthin prevented oxidative stress in heart and kidneys of isoproterenol-administered aged rats / J Diet Suppl 15:42~54
Anderson JW / 1999 / Effect of fermented milk (yogurt) containing Lactobacillus acidophilus L1 on serum cholesterol in hypercholesterolemic humans / J Am Coll Nutr 18:43~50
Ahmed SM / 2017 / Efficacy of gold nanoparticles against isoproterenol induced acute myocardial infarction in adult male albino rats / Ultrastruct Pathol 41:168~185
Al-Hadi HA / 2009 / Cardiac marcers in the early diagnosis and management of patients with acute coronary syndrome / Sultan Qaboos Univ Med J 9:231~246
Alam MN / 2017 / Astaxanthin prevented oxidative stress in heart and kidneys of isoproterenol-administered aged rats / J Diet Suppl 15:42~54
Anderson JW / 1999 / Effect of fermented milk (yogurt) containing Lactobacillus acidophilus L1 on serum cholesterol in hypercholesterolemic humans / J Am Coll Nutr 18:43~50
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