Pharmacokinetic Study of Florfenicol in Healthy and Vibriosis-infected Pseudosciaena crocea after Oral Administration

Wang, Li; Han, Yan-nan; Jin, Shan; Ma, Yin; Wang, Guo-liang; Zhao, Qing-song; Chen, Yin-er

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자료유형: 학술저널

저자정보: Wang, Li (School of Marine, Ningbo University) Han, Yan-nan (School of Marine, Ningbo University) Jin, Shan (School of Marine, Ningbo University) Ma, Yin (School of Marine, Ningbo University) Wang, Guo-liang (School of Marine, Ningbo University) Zhao, Qing-song (School of Marine, Ningbo University) Chen, Yin-er (School of Marine, Ningbo University)

저널정보: 한국응용생명화학회 Journal of applied biological chemistry Journal of applied biological chemistry 제58권 제4호

발행연도: 2015.1

수록면: 363 - 368 (6page)

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연구주제

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The pharmacokinetics of florfenicol were studied in healthy and vibriosis-infected large yellow croaker (Pseudosciaena crocea) following administration of a single oral dose of $20mg{\cdot}kg^{-1}$ at $25{\pm}2^{\circ}C$. After oral administration, florfenicol levels in tissues (liver, kidney, muscle, serum, and skin) were analyzed using high-performance liquid chromatography. A two-compartment open model was used to describe the pharmacokinetics of florfenicol following oral administration. Compared to the healthy group, the absorption rate of vibriosis-infected fish significantly decreased, peak-time ($T_{max}$) delayed, maximum concentration ($C_{max}$) declined, total body clearance decreased, the elimination half-life ($T_{1/2{\beta}}$) was extended, and the area under the curve increased. These results indicate that a $20mg{\cdot}kg^{-1}$ oral dose of florfenicol administered once daily continuously for 4 or 5 days can be used for the treatment of Vibrio alginolyticus infection in large yellow croaker (Pseudosciaena crocea).

#florfenicol #pharmacokinetics #Pseudosciaena crocea #Vibrio alginolyticus

참고문헌 (30)

참고문헌 신청

Bernt M / 1993 / Single dose pharmacokinetic study of florfenicol in Atlantic salmon(Salmo salar)in seawater at 11oC / Aquaculture 112:111

Bjorklund HV / 1992 / Temperature related absorption and excretion of oxolinic acid in rainbow trout(Oncorhynchus mykiss) / Aquaculture 102:17~27

Bowser PR / 2009 / Florfenicol residues in nile tilapia after 10d oral dosing in feed: effect of fish size / J aquatic animal health 21:7~14

Elema MO / 1995 / Bioavailability of flumequine after oral administration to Atlantic salmon (Salmo salar L.) / Aquaculture 136:209~219

Elema MO / 1996 / Bioavailability of oxtetrycline from medicated feed administered to Atlantic salmon(Salmo salar L. )in seawater / Aquaculture 143:7~14

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