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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 110 - 118 (9page)
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According to the expansion of lifespan, neuronal disorder based on inflammation has been social problem. Therefore, we isolated shikonin from Lithospermum erythrorhizon and evaluated anti-inflammatory effects of shikonin in lipopolysaccharide (LSP)-stimulated BV2 microglial cells. Shikonin dose-dependently inhibits the expression of the proinflammatory mediators, nitric oxide (NO), prostaglandin $E_2$ ($PGE_2$), and tumor necrosis factor-${\kappa}B$ (TNF-${\alpha}$) as well as their main regulatory genes and products such as inducible NO synthase (iNOS), cyclooxygenase-2 (COX-2), and TNF-${\alpha}$ in LPS-stimulated BV2 microglial cells. Additionally, shikonin suppressed the LPS-induced DNA-binding activity of nuclear factor-${\kappa}B$ (NF-${\kappa}B$) to regulate the key regulatory genes of the proinflammatory mediators, such as iNOS, COX-2, and TNF-${\alpha}$, accompanied with downregulation of reactive oxygen species (ROS) generation. The results indicate that shikonin may downregulate the expression of proinflammatory genes involved in the synthesis of NO, $PGE_2$, and TNF-${\alpha}$ in LPS-treated BV2 microglial cells by suppressing ROS and NF-${\kappa}B$. Taken together, our results revealed that shikonin exerts downregulation of proinflammatory mediators by interference the ROS and NF-${\kappa}B$ signaling pathway.
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참고문헌 (38)
참고문헌 신청
Andújar, I. / 2013 / Shikonin promotes intestinal wound healing in vitro via induction of TGF-βrelease in IEC-18 cells / Eur. J. Pharm. Sci 49:637~641
Block, M. L. / 2005 / Microglia and inflammation-mediated neurodegeneration: multiple triggers with a common mechanism / Prog. Neurobiol 76:77~98
Block, M. L. / 2007 / Microglia-mediated neurotoxicity:uncovering the molecular mechanism / Nat. Rev. Neurosci 8:57~69
Bonizzi, G. / 1999 / Reactive oxygen intermediatedependent NF-κB activation by interleukin-1β requires 5-lipoxygenase or NADPH oxidase activity / Mol. Cell. Biol 19:1950~1960
Camandola, S. / 2007 / NF-κB as a therapeutic target in neurodegenerative disease / Expert Opin. Ther. Targets 11:123~132
Block, M. L. / 2005 / Microglia and inflammation-mediated neurodegeneration: multiple triggers with a common mechanism / Prog. Neurobiol 76:77~98
Block, M. L. / 2007 / Microglia-mediated neurotoxicity:uncovering the molecular mechanism / Nat. Rev. Neurosci 8:57~69
Bonizzi, G. / 1999 / Reactive oxygen intermediatedependent NF-κB activation by interleukin-1β requires 5-lipoxygenase or NADPH oxidase activity / Mol. Cell. Biol 19:1950~1960
Camandola, S. / 2007 / NF-κB as a therapeutic target in neurodegenerative disease / Expert Opin. Ther. Targets 11:123~132
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