지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.3
- 수록면
- 77 - 88 (12page)
이용수
초록· 키워드
오류제보하기
Lithospermum erythrorhizon has long been used in traditional Asian medicine for the treatment of diseases, including skin cancer. The oral toxicity of a hexane extract of Lithospermum erythrorhizon root (LEH) was investigated in Beagle dogs by using single escalating doses, two-week dose range-finding, and 4-week oral repeat dosing. In the single dose-escalating oral toxicity study, no animal died, showed adverse clinical signs, or changes in body weight gain at LEH doses of up to 2,000 ㎎/㎏. In a 2 week dose range-finding study, no treatment-related adverse effects were detected by urinalysis, hematology, blood biochemistry, organ weights, or gross and histopathological examinations at doses of up to 500 ㎎ LEH/㎏/day. In the 4 week repeat-dose toxicity study, a weight loss or decreased weight gain was observed at 300 ㎎/㎏/day. Although levels of serum triglyceride and total bilirubin were increased in a dose dependent manner, there were no related morphological changes. Based on these findings, the sub-acute no observable adverse effect level for 4-week oral administration of LEH in Beagles was 100 ㎎/㎏/day.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
REFERENCES
참고문헌 (12)
참고문헌 신청
Chen, X. / 2002 / Cellular pharmacology studies of shikonin derivatives / Phytother. Res. 16:199~209
Rajasekar, S. / 2012 / In vitro and in vivo anticancer effects of Lithospermum erythrorhizon extract on B16F10 murine melanoma / J. Ethnopharmacol 144:335~345
Lee, C. C. / 2010 / Shikonin inhibits maturation of bone marrow-derived dendritic cells and suppresses allergic airway inflammation in a murine model of asthma / Br. J. Pharmacol. 161:1496~1511
Andújar, I. / 2013 / Shikonin promotes intestinal wound healing in vitro via induction of TGF-β release in IEC-18 cells / Eur. J. Pharm. Sci. 49:637~641
Karayannopoulou, M. / 2011 / Evaluation of the effectiveness of an ointment based on Alkannins/Shikonins on second intention wound healing in the dog / Can. J. Vet. Res. 75:42~48
Rajasekar, S. / 2012 / In vitro and in vivo anticancer effects of Lithospermum erythrorhizon extract on B16F10 murine melanoma / J. Ethnopharmacol 144:335~345
Lee, C. C. / 2010 / Shikonin inhibits maturation of bone marrow-derived dendritic cells and suppresses allergic airway inflammation in a murine model of asthma / Br. J. Pharmacol. 161:1496~1511
Andújar, I. / 2013 / Shikonin promotes intestinal wound healing in vitro via induction of TGF-β release in IEC-18 cells / Eur. J. Pharm. Sci. 49:637~641
Karayannopoulou, M. / 2011 / Evaluation of the effectiveness of an ointment based on Alkannins/Shikonins on second intention wound healing in the dog / Can. J. Vet. Res. 75:42~48
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UCI(KEPA) : I410-ECN-0101-2016-513-001366508