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논문 기본 정보

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학술저널
저자정보
Li, Tao (Department of Anesthesiology, China-Japan Union Hospital, Jilin University) Wan, Yingchun (Department of Endocrinology, China-Japan Union Hospital, Jilin University) Sun, Lijuan (Department of Endocrinology, China-Japan Union Hospital, Jilin University) Tao, Shoujun (Department of Anesthesiology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine) Chen, Peng (Department of Anesthesiology, China-Japan Union Hospital, Jilin University) Liu, Caihua (Department of Anaesthesiology, The Central Hospital of Wuhan Affiliated with Tongji Medical College of Huazhong University of Science and Technology) Wang, Ke (Department of Gynaecology and Obstetrics, China-Japan Union Hospital, Jilin University) Zhou, Changyu (Department of Gastroenterology, China-Japan Union Hospital, Jilin University) Zhao, Guoqing (Department of Anesthesiology, China-Japan Union Hospital, Jilin University)
저널정보
한국응용약물학회 Biomolecules & Therapeutics(구 응용약물학회지) Biomolecules & therapeutics 제27권 제4호
발행연도
2019.1
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414 - 422 (9page)

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There is accumulating evidence that microRNAs are emerging as pivotal regulators in the development and progression of neuropathic pain. MicroRNA-15a/16 (miR-15a/16) have been reported to play an important role in various diseases and inflammation response processes. However, whether miR-15a/16 participates in the regulation of neuroinflammation and neuropathic pain development remains unknown. In this study, we established a mouse model of neuropathic pain by chronic constriction injury (CCI) of the sciatic nerves. Our results showed that both miR-15a and miR-16 expression was significantly upregulated in the spinal cord of CCI rats. Downregulation of the expression of miR-15a and miR-16 by intrathecal injection of a specific inhibitor significantly attenuated the mechanical allodynia and thermal hyperalgesia of CCI rats. Furthermore, inhibition of miR-15a and miR-16 downregulated the expression of interleukin-$1{\beta}$ and tumor-necrosis factor-${\alpha}$ in the spinal cord of CCI rats. Bioinformatic analysis predicted that G protein-coupled receptor kinase 2 (GRK2), an important regulator in neuropathic pain and inflammation, was a potential target gene of miR-15a and miR-16. Inhibition of miR-15a and miR-16 markedly increased the expression of GRK2 while downregulating the activation of p38 mitogen-activated protein kinase and $NF-{\kappa}B$ in CCI rats. Notably, the silencing of GRK2 significantly reversed the inhibitory effects of miR-15a/16 inhibition in neuropathic pain. In conclusion, our results suggest that inhibition of miR-15a/16 expression alleviates neuropathic pain development by targeting GRK2. These findings provide novel insights into the molecular pathogenesis of neuropathic pain and suggest potential therapeutic targets for preventing neuropathic pain development.
#GRK2 #miR-15a/16 #Neuropathic pain #p38 MAPK

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참고문헌 (42)

참고문헌 신청
Ahmed, M. R / 2008 / Altered expression and subcellular distribution of GRK subtypes in the dopamine-depleted rat basal ganglia is not normalized by l-DOPA treatment / J. Neurochem 104:1622~1636 google schola Ambros, V / 2004 / The functions of animal microRNAs / Nature 431:350~355 google schola Andersen, H. H / 2014 / MicroRNAs as modulators and biomarkers of inflammatory and neuropathic pain conditions / Neurobiol. Dis 71:159~168 google schola Bartel, D. P / 2004 / MicroRNAs : genomics, biogenesis, mechanism, and function / Cell 116:281~297 google schola Bennett, G. J / 1988 / A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man / Pain 33:87~107 google schola

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