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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 72 - 76 (5page)
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Hypoxia-inducible factor $1{\alpha}\;(HIF1{\alpha})$ is a transcription factor that plays a key role in the adaptation of cells to low oxygen stress and oxygen homeostasis. The oxygen-dependent degradation (ODD) domain of $HIF1{\alpha}$ is responsible for the negative regulation of $HIF1{\alpha}$ in normoxia. The interactions of the $HIF1{\alpha}$ ODD domain with partner proteins such as von Hippel-Lindau tumor suppressor (pVHL) and p53 are mediated by two sequence motifs, the N- and C-terminal ODD(NODD and CODD). Multiple sequence alignment with $HIF1{\alpha}$ homologs from human, monkey, pig, rat, mouse, chicken, frog, and zebrafish has demonstrated that the NODD and CODD motifs have noticeably high conservation of the primary sequence across different species and isoforms. In this study, we carried out molecular dynamics simulation of the structure of the $HIF1{\alpha}$ CODD motif in complex with the p53 DNA-binding domain (DBD). The structure reveals specific functional roles of highly conserved residues in the CODD sequence motif of $HIF1{\alpha}$ for the recognition of p53.
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참고문헌 (20)
참고문헌 신청
Bruick, R.K. / 2002 / Transcription. Oxygen sensing gets a second wind / Science 295:807~808
Fels, D.R. / 2005 / HIF-1α and p53: the ODD couple? / Trends Biochem Sci 30:426~429
Hansson, L.O. / 2002 / Two sequence motifs from HIF-1α bind to the DNA-binding site of p53 / Proc. Natl. Acad. Sci. USA 99:10305~10309
Hara, S / 2001 / Expression and characterization of hypoxia-inducible factor (HIF)-3α in human kidney: suppression of HIF-mediated gene expression by HIF-3α / Biochem. Biophys. Res. Commun 287:808~813
Hon, W.C. / 2002 / Structural basis for the recognition of hydroxyproline in HIF-1α by pVHL / Nature 417:975~978
Fels, D.R. / 2005 / HIF-1α and p53: the ODD couple? / Trends Biochem Sci 30:426~429
Hansson, L.O. / 2002 / Two sequence motifs from HIF-1α bind to the DNA-binding site of p53 / Proc. Natl. Acad. Sci. USA 99:10305~10309
Hara, S / 2001 / Expression and characterization of hypoxia-inducible factor (HIF)-3α in human kidney: suppression of HIF-mediated gene expression by HIF-3α / Biochem. Biophys. Res. Commun 287:808~813
Hon, W.C. / 2002 / Structural basis for the recognition of hydroxyproline in HIF-1α by pVHL / Nature 417:975~978
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