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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 51 - 58 (8page)
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초록· 키워드
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Hypoxia-inducible factors (HIFs) are transcription factors
that activate the transcription of target genes involved
in crucial aspects of cancer development. This
study investigated the expression of HIFs and their
contribution to the regulation of target genes related
to angiogenesis and glucose metabolism in gastric
cancer. The data showed that HIFs were over-expressed
in gastric cancer and that activation of the target
genes was observed mainly in the early stages.
Moreover, the results of the present study revealed that
only HIF-1α, but not HIF-2α dimerizes with HIF-1β and
then regulates expression of target genes in response
to hypoxia. The results of the present study demonstrate
that HIF-1α and HIF-1β enhances expression of
VEGF and glucose metabolism-related genes in response
to hypoxia in gastric cancer. These data offer
important information regarding HIF pathways in the
development of gastric cancer.
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등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
Bongkun Choi, Yousin Suh / 2007 / Downregulation of regenerating islet-derived 3 alpha (REG3A)in primary human gastric adenocarcinomas / Experimental and Molecular Medicine 3
Brusselmans K / 2001 / Hypoxia-inducible factor-2alpha (HIF-2alpha) is involved in the apoptotic response to hypoglycemia but not to hypoxia / J Biol Chem 276 : 39192 ~ 6
Carroll VA / 2005 / Targeting the molecular basis for tumour hypoxia / Expert Rev Mol Med 7 : 1 ~ 16
Carroll VA / 2006 / Role of hypoxia-inducible factor (HIF)-1alpha versus HIF-2alpha in the regulation of HIF target genes in response to hypoxia, insulin-like growth factor-I
Ema M / 1997 / A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and
Brusselmans K / 2001 / Hypoxia-inducible factor-2alpha (HIF-2alpha) is involved in the apoptotic response to hypoglycemia but not to hypoxia / J Biol Chem 276 : 39192 ~ 6
Carroll VA / 2005 / Targeting the molecular basis for tumour hypoxia / Expert Rev Mol Med 7 : 1 ~ 16
Carroll VA / 2006 / Role of hypoxia-inducible factor (HIF)-1alpha versus HIF-2alpha in the regulation of HIF target genes in response to hypoxia, insulin-like growth factor-I
Ema M / 1997 / A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and
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고래의 게놈에서 hypoxia-inducible factor binding site의 예측과 target gene에 대한 분석
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Constitutive stabilization of hypoxia-inducible factor alpha selectively promotes the self-renewal of mesenchymal progenitors and maintains mesenchymal stromal cells in an undifferentiated state
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Association of DNA-dependent protein kinase w ith hypoxia inducible factor-1 and its im plication in resistance to anticancer drugs in hypoxic tumor cells
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Mechanism of the natural product moracin-O derived MO-460 and its targeting protein hnRNPA2B1 on HIF-1α inhibition
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Effects of echinomycin on endothelin-2 expression and ovulation in immature rats primed with gonadotropins
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Functional Role of a Conserved Sequence Motif in the Oxygen-dependent Degradation Domain of Hypoxia-inducible Factor 1α in the Recognition of p53
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Crosstalk between FLS and chondrocytes is regulated by HIF-2α-mediated cytokines in arthritis
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Nur77 upregulates HIF-α by inhibiting pVHL-mediateddegradation
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Hypoxia and aging
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The pleckstrin homology domain of phospholipase D1 accelerates EGFR endocytosis by increasing the expression of the Rab5 effector, rabaptin-5
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