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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2004.1
- 수록면
- 233 - 242 (10page)
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Tumor hypoxia contributes to the progression of a malignant phenotype and resistance to ioniz-ing radiation and anticancer drug therapy. Many mediated by expression of specific set of genes whose relation to therapy resistance is porly understod. In this study, we revealed that DNA-dependent protein kinase (DNA-PK), which plays a crucial role in DNA double strand break repair, would be involved in regulation of hypoxia inducible factor-1 (HIF-1). HIF-1β-defi-cient cells showed constitutively reduced ex-presion and DNA-binding activity of Ku, the regulatory subunit of DNA-PK. Under hypoxic condition, the expresion and activity of DNA- increase in HIF-1α expresion. Our result also demonstrated that DNA-PK could directly in-teract with HIF-1, and especially DNA-PKcs, the catalytic subunit of DNA-PK, could be involved in phosphorylation of HIF-1α, suggesting the posibility that the enhanced expresion of DNA- PK under hypoxic condition might atribute to modulate HIF-1α stabilization. Thus, the corel-ated regulation of DNA-PK with HIF-1 could cells, and it provides new evidence for developing therapeutic strategies enhancing the efficacy of cancer therapy in hypoxic tumor cells.
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참고문헌 (28)
참고문헌 신청
/ / Absence of p350 subunit of DNA-activated protein kinase from a radiosensitive human cell line : 1183 ~ 195 5
/ / Hypoxia causes the activation of nuclear factor kappa B through the phos-phorylation of I kappa B alpha on tyrosine residues : 1425 ~ 30
/ / Phosphorylation of trans-cription factor Sp1 by the DNA-dependent protein kinase : 279 ~ 86
/ / c-Jun is phosphorylated by the DNA-dependent protein kinase in vitro definition of the minimal kinase recognition motif : 1289 ~ 95
/ 1997 / Functions of the DNA dependent protein kinase : 221 ~ 61
/ / Hypoxia causes the activation of nuclear factor kappa B through the phos-phorylation of I kappa B alpha on tyrosine residues : 1425 ~ 30
/ / Phosphorylation of trans-cription factor Sp1 by the DNA-dependent protein kinase : 279 ~ 86
/ / c-Jun is phosphorylated by the DNA-dependent protein kinase in vitro definition of the minimal kinase recognition motif : 1289 ~ 95
/ 1997 / Functions of the DNA dependent protein kinase : 221 ~ 61
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