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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 849 - 857 (9page)
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The mechanisms that regulate angiogenesis in hypoxia
or hypoxic microenvironment are modulated by
several pro- and antiangiogenic factors. Hypoxia-inducible
factors (HIFs) have been established as the basic
and major inducers of angiogenesis, but understanding
the role of interacting proteins is becoming
increasingly important to elucidate the angiogenic
processes of a hypoxic response. In particular, with regard
to wound healing and the novel therapies for vascular
disorders such as ischemic brain and heart attack,
it is essential to gain insights in the formation and
regulation of HIF transcriptional machineries related to
angiogenesis. Further, identification of alternative
ways of inhibiting tumor growth by disrupting the
growth-triggering mechanisms of increasing vascular
supply via angiogenesis depends on the knowledge of
how tumor cells develop their own vasculature. Here,
we review our findings on the interactions of basic
HIFs, HIF-1α and HIF-2α, with their regulatory binding
proteins, histone deacetylase 7 (HDAC7) and translation
initiation factor 6 (Int6), respectively. The present
results and discussion revealed new regulatory interactions
of HIF-related mechanisms.
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등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Asano K / 1997 / The translation initiation factor eIF3-p48 subunit is encoded by int-6, a site of frequent integration by the mouse mammary tumor virus genome / J Biol Chem
Bertos NR / 2001 / Class II histone deacetylases:Structure, function, and regulation / Biochem Cell Biol 79 : 243 ~ 252
Brown JM / 1998 / The unique physiology of solid tumors: Opportunities (and problems) for cancer therapy / Cancer Res 58 : 1408 ~ 1416
Brunnberg S / 2003 / The basic helix-loop-helix-PAS protein ARNT functions as a potent coactivator of estrogen receptor-dependent transcription / Proc Natl Acad Sci USA 100 :
Carroll VA / 2006 / Role of hypoxia-inducible factor (HIF)-1α versus HIF-2α in the regulation of HIF target genes in response to hypoxia, insulin-like growth factor-I, or l
Bertos NR / 2001 / Class II histone deacetylases:Structure, function, and regulation / Biochem Cell Biol 79 : 243 ~ 252
Brown JM / 1998 / The unique physiology of solid tumors: Opportunities (and problems) for cancer therapy / Cancer Res 58 : 1408 ~ 1416
Brunnberg S / 2003 / The basic helix-loop-helix-PAS protein ARNT functions as a potent coactivator of estrogen receptor-dependent transcription / Proc Natl Acad Sci USA 100 :
Carroll VA / 2006 / Role of hypoxia-inducible factor (HIF)-1α versus HIF-2α in the regulation of HIF target genes in response to hypoxia, insulin-like growth factor-I, or l
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봉독의 HIF-1α 발현감소를 통한 혈관신생 억제효과
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Mechanism of the natural product moracin-O derived MO-460 and its targeting protein hnRNPA2B1 on HIF-1α inhibition
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Tissue microarray를 이용한 여러 암에서의 thymosin β4, vascular endothelial growth factor, 및 hypoxia-inducible factor-1α 발현양상 연구
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Phospholipase D activates HIF-1-VEGF pathway via phosphatidic acid
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Functional Role of a Conserved Sequence Motif in the Oxygen-dependent Degradation Domain of Hypoxia-inducible Factor 1α in the Recognition of p53
Genomics & informatics
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Effects of echinomycin on endothelin-2 expression and ovulation in immature rats primed with gonadotropins
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Gene Expression Analysis of Gα Knockout Mouse Embryos Reveals Perturbations in Gα Signaling Related to Angiogenesis and Hypoxia
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Nur77 upregulates HIF-α by inhibiting pVHL-mediateddegradation
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