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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 479 - 485 (7page)
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초록· 키워드
오류제보하기
Hypoxia-inducible factor 1α (HIF-1α) is rapidly degraded
by the ubiquitin-proteasome pathway under
normoxic conditions. Ubiquitination of HIF-1α is mediated
by interaction with von Hippel-Lindau tumor suppressor
protein (pVHL). In our previous report, we
found that hypoxia-induced active signal transducer
and activator of transcription3 (STAT3) accelerated the
accumulation of HIF-1α protein and prolonged its
half-life in solid tumor cells. However, its specific
mechanisms are not fully understood. Thus, we examined
the role of STAT3 in the mechanism of pVHL-mediated
HIF-1α stability. We found that STAT3 interacts
with C-terminal domain of HIF-1α and stabilizes HIF-1α
by inhibition of pVHL binding to HIF-1α. The binding between HIF-1α and pVHL, negative regulator of
HIF-1α stability, was interfered dose-dependently by
overexpressed constitutive active STAT3. Moreover,
we found that the enhanced HIF-1α protein levels by active
STAT3 are due to decrease of poly-ubiquitination
of HIF-1α protein via inhibition of interaction between
pVHL and HIF-1α. Taken together, our results suggest
that STAT3 decreases the pVHL-mediated ubiquitination
of HIF-1α through competition with pVHL for binding
to HIF-1 α, and then stabilizes HIF-1α protein levels.
목차
등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
Berra E / 2006 / The hypoxia-induciblefactor hydroxylases bring fresh air into hypoxia signaling / EMBO Rep 7 : 41 ~ 5
Bowman T / 2000 / Stats in oncogenesis / Oncogene 19 : 2474 ~ 88
Bruick RK / 2001 / conserved family of prolyl- 4-hydroxylases that modify HIF / Science 294 : 1337 ~ 40
Bu-Yeon Kim / 2008 / Nur77 upregulates HIF-α by inhibiting pVHL-mediateddegradation / Experimental and Molecular Medicine 40 (1) : 71 ~ 83
Bunn HF / 1996 / Oxygen sensing and molecular adaptation to hypoxia / Physiol Rev 76 : 839 ~ 85
Bowman T / 2000 / Stats in oncogenesis / Oncogene 19 : 2474 ~ 88
Bruick RK / 2001 / conserved family of prolyl- 4-hydroxylases that modify HIF / Science 294 : 1337 ~ 40
Bu-Yeon Kim / 2008 / Nur77 upregulates HIF-α by inhibiting pVHL-mediateddegradation / Experimental and Molecular Medicine 40 (1) : 71 ~ 83
Bunn HF / 1996 / Oxygen sensing and molecular adaptation to hypoxia / Physiol Rev 76 : 839 ~ 85
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Nur77 upregulates HIF-α by inhibiting pVHL-mediateddegradation
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