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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Objectives: This study was conducted to evaluate the effects of Pueraria lobata (PL) extract on obesity related hormones in rats with estrogen deficiency. Methods: The experiments were performed with the use of ovariectomized rats as estrogen-deficient obesity rat model. They were grouped Normal (sham operation group), Control (ovariectomy group), 50 mg/kg PL (ovariectomy group＋50 mg/kg of PL), 100 mg/kg PL (ovariectomy group＋100 mg/kg of PL), 200 mg/kg PL (ovariectomy group＋200 mg/kg of PL). PL extract was orally administered for 8 weeks once a day. Body weights and serum levels of hormones, such as leptin, estradiol, cholecystokinin (CCK), ghrelin, and adiponectin were estimated by ELISA. Results: PL extract significantly decreased body weight, the serum levels of leptin in estrogen-deficient obesity rats. PL extract significantly increased the serum levels of estradiol and CCK. However, PL extract did not directly effect on the levels of ghrelin and adiponectin in estrogen-deficient obesity rats. Conclusions: It is concluded that PL extract reduced body weight, and regulate the hormones related to energy metabolism. PL extract decreased the serum levels of leptin. PL extract increased the serum levels of estradiol and CCK. These results indicate that PL might have potentials for treatment of obesity and complications during the menopause caused by estrogen-deficiency.
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참고문헌 (22)
참고문헌 신청
양미성 / 2008 / 폐경기 비만의 임상적 의의에 대한 문헌적 고찰 / 한방비만학회지 8(2):1~13
Kim JG / 2009 / Management of menopausal women / Kunja Publisher :341~347
Korea Centers for Disease Control and Prevention (KCDC) / 2015 Health behavior and chronic disease statistics
Hamed S / 2015 / Estrogen metabolism and breast cancer / Cancer Lett 356(20):231~243
김정민 / 2017 / 동물실험에서 한약제재 경구투여가 비만에 미치는 영향에 대한 국내 연구보고 고찰 - 2010년 이후 발표된 논문을 중심으로 / 한방재활의학과학회지 27(3):13~32
Kim JG / 2009 / Management of menopausal women / Kunja Publisher :341~347
Korea Centers for Disease Control and Prevention (KCDC) / 2015 Health behavior and chronic disease statistics
Hamed S / 2015 / Estrogen metabolism and breast cancer / Cancer Lett 356(20):231~243
김정민 / 2017 / 동물실험에서 한약제재 경구투여가 비만에 미치는 영향에 대한 국내 연구보고 고찰 - 2010년 이후 발표된 논문을 중심으로 / 한방재활의학과학회지 27(3):13~32
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