지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.9
- 수록면
- 143 - 149 (7page)
이용수
초록· 키워드
오류제보하기
Excessive exposure to estrogens is the most important risk factor for the development of hormone-sensitive cancers, especially breast cancer. Estrogen stimulates the expression of genes and proteins involved in cell proliferation by binding to estrogen receptor (ER). Another possible mechanism of ER-independent carcinogenicity of estrogens is based on the hydroxylation of estradiol resulting in the formation of catechol estrogens. Catechol estrogen 4-hydroxyestradiol (4-OHE₂) is further oxidized to catechol estrogen-3,4-quinones, the major carcinogenic metabolites of estrogens. Evidence increasingly supports the critical role of 4-OHE₂ in hormonal carcinogenesis via DNA adduct formation or production of reactive oxygen species, which finally contribute to the transformation of normal mammary epithelial cells and the enhanced growth of breast cancer cells. It is also reported that the level of 4-OHE₂ or its quinones is highly up-regulated in urine or tissues of breast cancer patients. Thus, we highlight the oncogenic roles of 4-OHE₂ in catechol estrogen-induced breast carcinogenesis.
목차
INTRODUCTION
CONCLUSION
REFERENCES
참고문헌 (52)
참고문헌 신청
[학술지(정기간행물)] - Belous AR / 2007 / Cytochrome p450 1b1-mediated estrogen metabolism results in estrogen-deoxyribonucleoside adduct formation / Cancer Res 67 : 812 ~ 817
[학술지(정기간행물)] - Castagnetta LA / 2002 / Tissue content of hydroxyestrogens in relation to survival of breast cancer patients / Clin Cancer Res 8 : 3146 ~ 3155
[학술지(정기간행물)] - Cavalieri E / 2006 / Catechol estrogen quinones as initiators of breast and other human cancers: Implications for biomarkers of susceptibility and cancer prevention / Biochim Biophys Acta 1766 : 63 ~ 78
[학술지(정기간행물)] - Cavalieri E / 2000 / Estrogens as endogenous genotoxic agents--DNA adducts and mutations / J Natl Cancer Inst Monogr : 75 ~ 93
[학술지(정기간행물)] - Cavalieri E / 2006 / Catechol quinones of estrogens in the initiation of breast, prostate, and other human cancers: Keynote lecture / Ann N Y Acad Sci 1089 : 286 ~ 301
[학술지(정기간행물)] - Castagnetta LA / 2002 / Tissue content of hydroxyestrogens in relation to survival of breast cancer patients / Clin Cancer Res 8 : 3146 ~ 3155
[학술지(정기간행물)] - Cavalieri E / 2006 / Catechol estrogen quinones as initiators of breast and other human cancers: Implications for biomarkers of susceptibility and cancer prevention / Biochim Biophys Acta 1766 : 63 ~ 78
[학술지(정기간행물)] - Cavalieri E / 2000 / Estrogens as endogenous genotoxic agents--DNA adducts and mutations / J Natl Cancer Inst Monogr : 75 ~ 93
[학술지(정기간행물)] - Cavalieri E / 2006 / Catechol quinones of estrogens in the initiation of breast, prostate, and other human cancers: Keynote lecture / Ann N Y Acad Sci 1089 : 286 ~ 301
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UCI(KEPA) : I410-ECN-0101-2018-510-003599268