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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 349 - 353 (5page)
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Purpose: The expression of epithelial progenitor cells (EPCs) in rat vagina was recently reported. The aims were to investigate the effects of estrogen on vaginal EPCs in the oophorectomized female rat model. Materials and Methods: Female Sprague-Dawley rats (230–240 g, n=30) were divided into 3 groups: control (n=10), bilateral oophorectomy (OVX, n=10), and bilateral OVX followed by subcutaneous injections of 17β-estradiol (50 µg/kg/day, n=10). After 4 weeks, the expression of EPC-specific markers (CD44, estrogen receptor alpha [ERα], and progesterone receptor) were evaluated by immunohistochemistry and Western blot. Results: The CD44/ERα double-labeled cells were mainly expressed in basal cell layers and suprabasal layers as shown by confocal immunofluorescence. Confocal microscopy revealed that the number of CD44+/ERα+ cells decreased in the OVX group compared with the controls but was similar to control levels in rats receiving estrogen replacements. The protein expression of CD44 and ERα decreased after OVX and was restored to control levels after estrogen supplementation. Conclusions: Markers of EPCs were expressed in the vagina, and the expression of resident EPCs was regulated by estrogen. These findings imply that resident EPCs may have an important role in the regeneration of vaginal mucosa by estrogen replacement.
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참고문헌 (18)
참고문헌 신청
Laumann EO / 1999 / Sexual dysfunction in the United States : prevalence and predictors / JAMA 281:537~544
Jannini EA / 2014 / Beyond the G-spot : clitourethrovaginal complex anatomy in female orgasm / Nat Rev Urol 11:531~538
Park K / 2008 / Expression of aquaporin water channels in rat vagina : potential role in vaginal lubrication / J Sex Med 5:77~82
Blaskewicz CD / 2011 / Structure and function of intercellular junctions in human cervical and vaginal mucosal epithelia / Biol Reprod 85:97~104
Wira CR / 2005 / Epithelial cells in the female reproductive tract : a central role as sentinels of immune protection / Am J Reprod Immunol 53:65~76
Jannini EA / 2014 / Beyond the G-spot : clitourethrovaginal complex anatomy in female orgasm / Nat Rev Urol 11:531~538
Park K / 2008 / Expression of aquaporin water channels in rat vagina : potential role in vaginal lubrication / J Sex Med 5:77~82
Blaskewicz CD / 2011 / Structure and function of intercellular junctions in human cervical and vaginal mucosal epithelia / Biol Reprod 85:97~104
Wira CR / 2005 / Epithelial cells in the female reproductive tract : a central role as sentinels of immune protection / Am J Reprod Immunol 53:65~76
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