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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Objectives Standardization of head size is essential for the volume study. Cortical thickness analyses are increasingly being used in many fields of neuroscience. However, it is not established whether head size correction should be done for thickness study. Methods Using the Open Access Series of Imaging Studies data, we determined cortical thickness of 316 cognitively normal participants aged 18-94 with FreeSurfer. The association between head size and cortical thickness of whole cortical mantle and in each lobe among age tertile groups was assessed. Estimated total intracranial volume (eTIV) was calculated for determining head size. Results Across all participants, cortical thickness in whole brain except some areas in cingulate and insula decreased with aging. eTIV had positive correlation with the thickness of frontal, parietal, occipital and whole brain areas. However, the age effect was not shown in whole brain of the first tertile group and in cingulate areas of the third tertile group. eTIV had negative correlation with the thickness of cingulate in the third tertile group. Gender effects were shown in some areas in third tertile group, but it would be due to difference of head size. Conclusions These findings suggest that head size standardization might be done especially in older population and in studies of paralimbic areas.
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참고문헌 (36)
참고문헌 신청
Rosas HD / 2002 / Regional and progressive thinning of the cortical ribbon in Huntington’s disease / Neurology 58:695~701
Salat DH / 2004 / Thinning of the cerebral cortex in aging / Cereb Cortex 14:721~730
Bakkour A / 2009 / The cortical signature of prodromal AD: regional thinning predicts mild AD dementia / Neurology 72:1048~1055
Kuperberg GR / 2003 / Regionally localized thinning of the cerebral cortex in schizophrenia / Arch Gen Psychiatry 60:878~888
Lan MJ / 2014 / Cortical thickness differences between bipolar depression and major depressive disorder / Bipolar Disord 16:378~388
Salat DH / 2004 / Thinning of the cerebral cortex in aging / Cereb Cortex 14:721~730
Bakkour A / 2009 / The cortical signature of prodromal AD: regional thinning predicts mild AD dementia / Neurology 72:1048~1055
Kuperberg GR / 2003 / Regionally localized thinning of the cerebral cortex in schizophrenia / Arch Gen Psychiatry 60:878~888
Lan MJ / 2014 / Cortical thickness differences between bipolar depression and major depressive disorder / Bipolar Disord 16:378~388
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