지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Idiopathic normal-pressure hydrocephalus (INPH) is considered a potentially treatable neurological dis- order by shunt surgery and characterized by a triad of symptoms including gait disturbance, cognitive impairment and urinary dysfunction. Although disorders of white matter are generally viewed as the principal pathological fea- tures of INPH, analysis of cortical features are important since the destruction of neural tracts could be associated with cortical structural changing. The aim of the study was to determine whether there was any relationship between gait parameter and structural features of cerebral cortex in INPH patients. Gait parameters were measured as fol- lows: step width, toe in/out angle, coefficient of variation (CV) value of stride length, CV value of stride time. After obtaining individual brain MRI of patients with INPH and hemispheric cortical surfaces were automatically extracted from each MR volume, which reconstructed the inner and outer cortical surface. Then, cortical thickness, surface area, and volume were calculated from the cortical surface. As a result, step width was positively correlated with bilateral postcentral gyrus and left precentral gyrus, and toe in/out was positively correlated with left posterior pari- etal cortex and left insula. Also, the CV value of stride length showed positive correlation in the right superior frontal sulcus, left insula, and the CV value of stride time showed positive correlation in the right superior frontal sulcus. Unique parameter of cerebral cortical changes, as measured using MRI, might underline impairments in distinct gait parameters in patients with INPH.
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등록된 정보가 없습니다.
참고문헌 (54)
참고문헌 신청
Adams RD / 1965 / Symptomatic Occult Hydrocephalus with “Normal” Cerebrospinal-Fluid Pressure.A Treatable Syndrome / N Engl J Med 273:117~126
Kato T / 2011 / Segmental copy number loss of SFMBT1 gene in elderly individuals with ventriculomegaly:a community-based study / Intern Med 50(4):297~303
Takahashi Y / 2011 / Familial normal pressure hydrocephalus (NPH) with an autosomal-dominant inheritance: a novel subgroup of NPH / J Neurol Sci 308(1-2):149~151
Bech-Azeddine R / 2007 / Idiopathic normal-pressure hydrocephalus: clinical comorbidity correlated with cerebral biopsy findings and outcome of cerebrospinal fluid shunting / J Neurol Neurosurg Psychiatry 78(2):157~161
Cabral D / 2011 / Frequency of Alzheimer’s disease pathology at autopsy in patients with clinical normal pressure hydrocephalus / Alzheimers Dement 7(5):509~513
Kato T / 2011 / Segmental copy number loss of SFMBT1 gene in elderly individuals with ventriculomegaly:a community-based study / Intern Med 50(4):297~303
Takahashi Y / 2011 / Familial normal pressure hydrocephalus (NPH) with an autosomal-dominant inheritance: a novel subgroup of NPH / J Neurol Sci 308(1-2):149~151
Bech-Azeddine R / 2007 / Idiopathic normal-pressure hydrocephalus: clinical comorbidity correlated with cerebral biopsy findings and outcome of cerebrospinal fluid shunting / J Neurol Neurosurg Psychiatry 78(2):157~161
Cabral D / 2011 / Frequency of Alzheimer’s disease pathology at autopsy in patients with clinical normal pressure hydrocephalus / Alzheimers Dement 7(5):509~513
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