지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Objectives A growing body of evidence has suggested that morphologic changes in cerebellum may be implicated with pathophysiology of major depressive disorder (MDD). The aim of this study is to investigate a difference in the volume and cortical thickness of the specific region of cerebellum between patients with MDD and healthy controls (HC). Methods A total of 127 patients with MDD and 105 HC participated in this study and underwent T1-weighted structural magnetic resonance imaging. We analyzed volume and cortical thickness of each twelve cerebellum regions divided by left and right and the volume and cortical thickness of the whole cerebellum from T1-weigted image of participants. One-way analysis of covariance was used to investigate the volume and cortical thickness difference of total and specific regions between two groups adjusting for age, gender, medication, and total intracranial cavity volume. Results We found that the patients with MDD had significantly greater volume in the left cerebellum lobule III region [false discovery rate (FDR)-corrected p = 0.034] compared to HC. Also, our findings indicate that cortical thickness of left lobule VIIB (FDR-corrected p = 0.032) and lobule VIIIB (FDR-corrected p = 0.032) are significantly thinner in the patients with MDD compared with the HC. No significant volume and cortical thickness differences were observed in other sub-regions of the cerebellum. The volumes and cortical thickness of whole cerebellum between patients with MDD and HC did not differ significantly. Conclusions We observed the region-specific volume and cortical thickness difference in cerebellum between the patients with MDD and HC. The results of our study implicate that the information about structural alterations in cerebellum with further replicative studies might provide a stepping stone toward a specific marker to diagnose MDD.
목차
등록된 정보가 없습니다.
참고문헌 (65)
참고문헌 신청
Kessler RC / 2003 / The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R) / JAMA 289:3095~3105
Kupfer DJ / 2012 / Major depressive disorder: new clinical, neurobiological, and treatment perspectives / Lancet 379:1045~1055
Moussavi S / 2007 / Depression, chronic diseases, and decrements in health: results from the World Health Surveys / Lancet 370:851~858
Zhang WN / 2013 / The neural correlates of reward-related processing in major depressive disorder: a meta-analysis of functional magnetic resonance imaging studies / J Affect Disord 151:531~539
Kaiser RH / 2015 / Largescale network dysfunction in major depressive disorder: a meta-analysis of resting-state functional connectivity / JAMA Psychiatry 72:603~611
Kupfer DJ / 2012 / Major depressive disorder: new clinical, neurobiological, and treatment perspectives / Lancet 379:1045~1055
Moussavi S / 2007 / Depression, chronic diseases, and decrements in health: results from the World Health Surveys / Lancet 370:851~858
Zhang WN / 2013 / The neural correlates of reward-related processing in major depressive disorder: a meta-analysis of functional magnetic resonance imaging studies / J Affect Disord 151:531~539
Kaiser RH / 2015 / Largescale network dysfunction in major depressive disorder: a meta-analysis of resting-state functional connectivity / JAMA Psychiatry 72:603~611
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
소뇌
WITH CAP(COMPANION ANIMAL PRACTICE)
2019 .12
-
Childhood Sexual Abuse and Cortical Thinning in Adults With Major Depressive Disorder
PSYCHIATRY INVESTIGATION
2023 .04
-
Expected Emotional Usefulness and Emotional Preference in Individuals with Major Depressive Disorder
Clinical Psychopharmacology and Neuroscience
2016 .01
-
Reduced Cortical Thickness in the Temporal Pole, Insula, and Pars Triangularis in Patients with Panic Disorder
Yonsei Medical Journal
2017 .01
-
Cortical Thickness and Brain Glucose Metabolism in Healthy Aging
Journal of Clinical Neurology
2023 .03
-
Shape Deformation in the Brainstem of Medication-Naïve Female Patients with Major Depressive Disorder
PSYCHIATRY INVESTIGATION
2020 .01
-
Cerebellar Structural Abnormality in Autism Spectrum Disorder: A Magnetic Resonance Imaging Study
PSYCHIATRY INVESTIGATION
2023 .04
-
Frontal Alpha Asymmetry Moderated by Suicidal Ideation in Patients with Major Depressive Disorder: A Comparison with Healthy Individuals
Clinical Psychopharmacology and Neuroscience
2020 .01
-
성인 아토피 피부염 환자의 우울증 동반에 따른 점증적 비용 부담: 후향적 단면연구
보건의료기술평가
2021 .12
-
Immunoreactivity of PCNA in the Cerebellum of Developing Guinea Pig
International Journal of Oral Biology
2018 .01
-
Cortical Morphometric Abnormality and Its Association with Working Memory in Children with Attention-Deficit/Hyperactivity Disorder
PSYCHIATRY INVESTIGATION
2021 .01
-
Multiple Complement Pathway-related Proteins Might Regulate Immunopathogenesis of Major Depressive Disorder
Clinical Psychopharmacology and Neuroscience
2023 .05
-
Alterations in the Occipital Cortex of Drug-Naive Adults With Major Depressive Disorder: A Surface-Based Analysis of Surface Area and Cortical Thickness
PSYCHIATRY INVESTIGATION
2021 .10
-
Comparison of Electroencephalography (EEG) Coherence between Major Depressive Disorder (MDD) without Comorbidity and MDD Comorbid with Internet Gaming Disorder
Journal of Korean Medical Science
2017 .01
-
Reduced Temporal Activation During a Verbal Fluency Task is Associated with Poor Motor Speed in Patients with Major Depressive Disorder
PSYCHIATRY INVESTIGATION
2020 .01
-
Gender Differences in Depressive Symptom Profile: Results from Nationwide General Population Surveys in Korea
Journal of Korean Medical Science
2015 .01
-
Reduced Gray Matter Density in the Posterior Cerebellum of Patients with Panic Disorder : A Voxel-Based Morphometry Study
생물정신의학
2015 .01
-
BeMicroarray Analysis of the Major Depressive Disorder mRNA Profile Data
PSYCHIATRY INVESTIGATION
2015 .01
-
Effects of Uric Acid on the Alterations of White Matter Connectivity in Patients with Major Depression
PSYCHIATRY INVESTIGATION
2018 .01
-
Association Between White Matter Tract Integrity and Frontal-Executive Function in Non-Geriatric Adult Patients With Major Depressive Disorder
PSYCHIATRY INVESTIGATION
2024 .02
이 논문의 저자 정보
최근 본 자료
댓글(0)
0