지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제19권 제4호
- 발행연도
- 2021.11
- 수록면
- 640 - 652 (13page)
- DOI
- 10.9758/cpn.2021.19.4.640
이용수
초록· 키워드
오류제보하기
Objective: Subjective cognitive impairment (SCI) is associated with future cognitive decline. This study aimed to compare cortical thickness and local gyrification index (LGI) between individuals with SCI and normal control (NC) subjects.
Methods: Forty-seven participants (27 SCI and 20 NC) were recruited. All participants underwent brain magnetic resonance imaging scanning and were clinically assessed using the Consortium to Establish a Registry for Alzheimer’s Disease (CERAD) battery of tests. We compared cortical thickness and LGI between the two groups and analyzed correlations between cortical thickness/LGI and scores on CERAD protocol subtests in the SCI group for region of interests with significant between-group differences.
Results: Cortical thickness reduction in the left entorhinal, superior temporal, insular, rostral middle frontal, precentral, superior frontal, and supramarginal regions, and right supramarginal, precentral, insular, postcentral, and posterior cingulate regions was observed in the SCI compared to the NC group. Cortical thickness in these regions correlated with scores of constructional praxis, word list memory, word list recall, constructional recall, trail making test A, and verbal fluency under the CERAD protocol. Significantly decreased gyrification was observed in the left lingual gyrus of the SCI group. In addition, gyrification of this region was positively associated with scores of constructional praxis.
Conclusion: Our results may provide an additional reference to the notion that SCI may be associated with future cognitive impairment. This study may help clinicians to assess individuals with SCI who may progress to mild cognitive impairment and Alzheimer’s dementia.
목차
등록된 정보가 없습니다.
참고문헌 (60)
참고문헌 신청
Jessen F / 2014 / A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer’s disease / Alzheimers Dement 10:844~852
Glodzik-Sobanska L / 2007 / Subjective memory complaints : presence, severity and future outcome in normal older subjects / Dement Geriatr Cogn Disord 24:177~184
Amariglio RE / 2012 / Subjective cognitive complaints and amyloid burden in cognitively normal older individuals / Neuropsychologia 50:2880~2886
Visser PJ / 2009 / Prevalence and prognostic value of CSF markers of Alzheimer’s disease pathology in patients with subjective cognitive impairment or mild cognitive impairment in the DESCRIPA study : a prospective cohort study / Lancet Neurol 8:619~627
Saykin AJ / 2006 / Older adults with cognitive complaints show brain atrophy similar to that of amnestic MCI / Neurology 67:834~842
Glodzik-Sobanska L / 2007 / Subjective memory complaints : presence, severity and future outcome in normal older subjects / Dement Geriatr Cogn Disord 24:177~184
Amariglio RE / 2012 / Subjective cognitive complaints and amyloid burden in cognitively normal older individuals / Neuropsychologia 50:2880~2886
Visser PJ / 2009 / Prevalence and prognostic value of CSF markers of Alzheimer’s disease pathology in patients with subjective cognitive impairment or mild cognitive impairment in the DESCRIPA study : a prospective cohort study / Lancet Neurol 8:619~627
Saykin AJ / 2006 / Older adults with cognitive complaints show brain atrophy similar to that of amnestic MCI / Neurology 67:834~842
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