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논문 기본 정보

자료유형
학술저널
저자정보
Fei-Fei Si (Peking University Sixth Hospital Peking University Institute of Mental Health NHC Key Laboratory of) Lu Liu (Peking University Sixth Hospital Peking University Institute of Mental Health NHC Key Laboratory of) Hai-Mei Li (Peking University Sixth Hospital Peking University Institute of Mental Health NHC Key Laboratory of) Li Sun (Peking University Sixth Hospital Peking University Institute of Mental Health NHC Key Laboratory of) Qing-Jiu Cao (Peking University Sixth Hospital Peking University Institute of Mental Health NHC Key Laboratory of) Hanna Lu (Department of Psychiatry The Chinese University of Hong Kong) Yu-Feng Wang (Peking University Sixth Hospital Peking University Institute of Mental Health NHC Key Laboratory of) Qiu-Jin Qian (Peking University Sixth Hospital Peking University Institute of Mental Health NHC Key Laboratory of)
저널정보
대한신경정신의학회 PSYCHIATRY INVESTIGATION PSYCHIATRY INVESTIGATION 제18권 제7호
발행연도
2021.1
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679 - 687 (9page)

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Objective Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder in children and adolescents. The present study investigated the cortical morphology features and their relationship with working memory (WM).Methods In the present study, a total of 36 medication naive children with ADHD (aged from 8 to 15 years) and 36 age- and gendermatched healthy control (HC) children were included. The digit span test was used to evaluate WM. The magnetic resonance imaging (MRI) was used to examine the characteristics of cortical morphology. Firstly, we compared the cortical morphology features between two groups to identify the potential structural alterations of cortical volume, surface, thickness, and curvature in children with ADHD. Then, the correlation between the brain structural abnormalities and WM was further explored in children with ADHD.Results Compared with the HC children, the children with ADHD showed reduced cortical volumes in the left lateral superior temporal gyrus (STG) (p=6.67×10-6) and left anterior cingulate cortex (ACC) (p=3.88×10-4). In addition, the cortical volume of left lateral STG was positively correlated with WM (r=0.36, p=0.029).Conclusion Though preliminary, these findings suggest that the reduced cortical volumes of left lateral STG may contribute to the pathogenesis of ADHD and correlate with WM in children with ADHD.

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