지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제31권 제2호
- 발행연도
- 2008.1
- 수록면
- 148 - 153 (6page)
이용수
초록· 키워드
오류제보하기
Pioglitazone is a thiazolidinedione (TZD) class of antidiabetic drug acting mainly through activation of $PPAR{\gamma}$ which is a member of family of ligand activated nuclear hormone receptors. Clofibrate is an antilipemic drug acting through activation of $PPAR{\alpha}$. Despite the impressive antidiabetic activity of TZD, several side effects are implicated to use of this drug on some patient. Dual acting $PPAR{\alpha}/{\gamma}$ agonists have received increased attention to improve the profiles of the $PPAR{\gamma}$ agonists. Hence, we describe here synthesis of TZD and/or fibrate derivatives-containing homo- or copolymers, poly(TZD) 7, poly(TZD-MAA) 8, poly(TZD-FA) 9, poly(FA) 10, and poly(FA-MAA) 11. The contents of TZD unit in copolymers, poly(TZD-MAA) 8 and poly (TZD-FA) 9 were 25 and 19 mol %, respectively. The number average molecular weights of the polymers determined by GPC were in range from 466 to 12600 and the polydispersity indices were in the range of $1.2{\sim}13.3$.
목차
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