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논문 기본 정보

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학술저널
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Park, Yun-Sun (Department of Life Science, Research Center for Women's Diseases, Sookmyung Womens University) Choi, Ji-Won (Department of Life Science, Research Center for Women's Diseases, Sookmyung Womens University) Kim, Kun-Yong (Department of Life Science, Research Center for Women's Diseases, Sookmyung Womens University) Lim, Jong-Seok (Department of Life Science, Research Center for Women's Diseases, Sookmyung Womens University) Yoon, Suk-Joon (Department of Life Science, Research Center for Women's Diseases, Sookmyung Womens University) Yang, Young (Department of Life Science, Research Center for Women's Diseases, Sookmyung Womens University)
저널정보
한국응용약물학회 Biomolecules & Therapeutics(구 응용약물학회지) Biomolecules & therapeutics 제18권 제1호
발행연도
2010.1
수록면
77 - 82 (6page)

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Peroxisome proliferator-activated receptor $\gamma$ (PPAR${\gamma}$) is a ligand-activated transcription factor that is used as a target for anti-diabetic drug development. In a search for novel PPAR${\gamma}$ agonists, the $\beta$-carboxyethyl-rhodanine derivative SP1818 was identified. We report here the characteristics of SP1818 as a selective PPAR${\gamma}$ agonist. In transactivation assays, SP1818 selectively activated PPAR${\gamma}$, but the degree of PPAR${\gamma}$ stimulation was less than with $1{\mu}M$ rosiglitazone. SP1818 also stimulated glucose uptake in a concentration-dependent manner. The adipocyte differentiation markers adiponectin, scavenger receptor CD36 and aP2 were weakly induced by treatment with SP1818, and TRAP220 subunit was specifically recruited into PPAR${\gamma}$ activated by rosiglitazone but not PPAR${\gamma}$ activated by SP1818.

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