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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2004.6
- 수록면
- 137 - 142 (6page)
이용수
초록· 키워드
오류제보하기
The peroxisome proliferator-activated receptor γ (PPARγ) is the molecular target for a class of drugs, the antidiabetic thiazolidnediones (TZDs). The heterodimer of PPARγ with retinoid X receptor (RXR) plays a central role in the regulation of adipogenesis and insulin sensitization. We synthesized two chemicals, DANA87 and DANA88, sharing structural characteristics with TZDs. Given this structural similarity, it was hypothesized that DANA87 and DANA88 may act as PPARγ ligands. In transient transfection assays, DANA87 and DANA88 caused slight increases in the endogenous expression of a luciferase reporter gene containing the PPAR responsive element in 3T3-L1 preadipocytes. However, DANA87 and DANA88 significantly inhibited troglitazone-induced reporter gene activation when cells were treated with a combination of DANA87 or DANA 88 and troglitazone, one of the TZDs that activate PPARγ. These results suggest that DANA87 and DANA88 are not only weak agonists of PPARγ transactivation, but also competitively antagonize troglitazone-induced PPARγ reporter activity.
목차
영어 초록
INTRODUCTION
METHODS
RESULTS
DISCUSSION
Acknowledgements
REFERENCES
참고문헌 (39)
참고문헌 신청
[학술지(정기간행물)] - Brzozowski AM, / 1997 / Molecular basis of agonism and antagonism in the oestrogen receptor. 389 (6652) : 753 ~ 758
[학술지(정기간행물)] - Chaput E / 2000 / Fenofibrate and rosiglitazone lower serum triglycerides with opposing effects on body weight. 271 (2) : 445 ~ 450
[학술지(정기간행물)] - Corton JC / 2000 / Central role of PPARalpha in the mechanism of action of hepatocarcino- genic peroxisome proliferators. 448 (2) : 139 ~ 151
[학술지(정기간행물)] - Debril MB, / 201 / The pleiotropic functions of peroxisome proliferator-activated re- ceptor γ. 79 (1) : 30 ~ 47
[학술지(정기간행물)] - Fajas L, / 1997 / Molecular basis of agonism and antagonismin the oestrogen receptor. 389 (389) : 753 ~ 758
[학술지(정기간행물)] - Chaput E / 2000 / Fenofibrate and rosiglitazone lower serum triglycerides with opposing effects on body weight. 271 (2) : 445 ~ 450
[학술지(정기간행물)] - Corton JC / 2000 / Central role of PPARalpha in the mechanism of action of hepatocarcino- genic peroxisome proliferators. 448 (2) : 139 ~ 151
[학술지(정기간행물)] - Debril MB, / 201 / The pleiotropic functions of peroxisome proliferator-activated re- ceptor γ. 79 (1) : 30 ~ 47
[학술지(정기간행물)] - Fajas L, / 1997 / Molecular basis of agonism and antagonismin the oestrogen receptor. 389 (389) : 753 ~ 758
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UCI(KEPA) : I410-ECN-0101-2009-510-017341626