지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
이용수
초록· 키워드
오류제보하기
Thiazolidinediones (TZDs) are widely used antidiabetic drugs that activate the nuclear peroxisome proliferator-activated receptor γ (PPARγ), and thereby improve the metabolic abnormalities linking hypertriglyceridemia to diabetes, hyperglycemia, insulin resistance, and cardiovascular disease. To determine whether the PPARγ ligand troglitazone regulates lipid metabolism with sexual dimorphism, we examined the effects of troglitazone on circulating lipids, body weight and the expression of hepatic genes responsible for lipid metabolism in both sexes of C57BL/6J mice. Compared to mice fed a low fat control diet, both sexes of mice fed a troglitazone-treated low fat diet for 14 weeks did not exhibit changes in body weight gain, serum total cholesterol, HDL-cholesterol and LDL-cholesterol levels. However, serum triglycerides were significantly reduced in both sexes of mice, although these effects were more pronounced among males. Furthermore, troglitazone regulated the expression of hepatic genes critical far lipid and lipoprotein metabolism, the magnitudes of which were much higher in males compared to females, as evidenced by results for increased acyl-CoA oxidase and decreased apolipoprotein C-III mRNA levels. These results suggest that PPARγ activator troglitazone may exert sexually dimorphic control of serum triglycerides in part through the differential activation of PPARγ in liver between male and female mice.
목차
영어초록
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (33)
참고문헌 신청
[학술지(정기간행물)] - Jr,Brewer HB / 1999 / Hypertriglyceridemia: Changes in the plasma lipoproteins associated with an increased with an increased risk of cardiovascular disease / Am J Cardiol. 83 : 3 ~ 12
[학술지(정기간행물)] - E,Chaput / 2000 / Fenofibrate and rosiglitazone lower serum triglycerides with opposing effects on body weight / Biochem Biophys Res Commun. 271 : 445 ~ 450
[학술지(정기간행물)] - JC,Corton / 2000 / Central role of PPARalpha in the mechanism of action of hepatocarcinogenic peroxisome proliferators / Mutat Res. 448 : 139 ~ 151
[학술지(정기간행물)] - MB,Debril / 2001 / The pleiotropic functions of peroxisome proliferator-activated receptor / J Mol Med. 79 : 30 ~ 47
[학술지(정기간행물)] - C,Dreyer / 1992 / Control of the peroxisomal beta-oxidation pathway by a novel family of nuclear hormone receptors / Cell 68 : 879 ~ 887
[학술지(정기간행물)] - E,Chaput / 2000 / Fenofibrate and rosiglitazone lower serum triglycerides with opposing effects on body weight / Biochem Biophys Res Commun. 271 : 445 ~ 450
[학술지(정기간행물)] - JC,Corton / 2000 / Central role of PPARalpha in the mechanism of action of hepatocarcinogenic peroxisome proliferators / Mutat Res. 448 : 139 ~ 151
[학술지(정기간행물)] - MB,Debril / 2001 / The pleiotropic functions of peroxisome proliferator-activated receptor / J Mol Med. 79 : 30 ~ 47
[학술지(정기간행물)] - C,Dreyer / 1992 / Control of the peroxisomal beta-oxidation pathway by a novel family of nuclear hormone receptors / Cell 68 : 879 ~ 887
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Peroxisome Proliferator-activated Receptor γ Is Not Associated with Adipogenesis in Female Mice
대한의생명과학회지
2008 .09
-
Troglitazone Regulates white Adipose Tissue Metabolism by Activating Genes Involved in Fatty Acid β-Oxidation in High Fat Diet-fed C57BL/6J Mice
대한의생명과학회지
2006 .12
-
A549 기도상피세포에서 IL-8 전사와 분비에 미치는 Dexamethasone Troglitazone의 병합투여효과
천식 및 알레르기
2008 .01
-
갑상선암 세포주에서 Troglitazone의 분화 유도 효과
Annals of Surgical Treatment and Research
2004 .08
-
Troglitazone과 COX-2 억제제 병합 투여가 아교모세포종세포의 세포자멸사에 미치는 영향
Journal of Pathology and Translational Medicine
2007 .01
-
Peroxisome Proliferator-Activated Recetor γ Agonist Troglitazone Suppresses Cell Migration and Invasion by Regulating Glutathione Peroxidase 3 Expression and Epithelial-Mesenchymal Transitions in PC-3 Human Prostate Cancer Cells
한국실험동물학회 학술발표대회 논문집
2016 .02
-
Troglitazone Enhances the Apoptotic Response of DLD-1 Colon Cancer Cells to Photodynamic Therapy
Yonsei Medical Journal
2016 .01
-
Ubiquitination of p53 is Involved in Troglitazone Induced Apoptosis in Cervical Cancer Cells
Asian Pacific journal of cancer prevention : APJCP
2014 .01
-
Troglitazone and tumor inhibition: an evolving concept in the management of systemic malignancies
Radiation oncology journal : ROJ
2012 .01
-
Swim Training Improves Fitness in High Fat Diet-fed Female Mice
대한의생명과학회지
2010 .09
-
Sexually Dimorphic Control of Obesity and Skeletal Muscle Lipid Metabolism by Fenofibrate
대한의생명과학회지
2013 .03
-
Differential Regulation of Obesity by Swim Training in Female Sham-operated and Ovariectomized Mice
대한의생명과학회지
2011 .03
-
15-Hydroxyprostaglandin Dehydrogenase Is Associated with the Troglitazone-Induced Promotion of Adipocyte Differentiation in Human Bone Marrow Mesenchymal Stem Cells
Biomolecules & Therapeutics(구 응용약물학회지)
2010 .01
-
Fenofibrate, a peroxisome proliferator-activated receptor α-agonist, blocks lipopolysaccharide-induced inflammatory pathways in mouse liver
Annals of Hepato-Biliary-Pancreatic Surgery
2013 .08
-
Two Synthetic Ligands for Peroxisome Proliferator-Activated Receptor γ
대한의생명과학회지
2004 .06
-
오가피 에탄올 추출물이 마우스의 체중 및 혈청내 지질 함량에 미치는 효과
동의생리병리학회지
2006 .01
-
17β-estradiol Represses White Adipose Tissue Metabolism by Inhibiting PPARγ in High Fat Diet-induced Obese Female Ovariectomized Mice
대한의생명과학회지
2009 .09
-
Proteome analysis of differentially expressed proteins in the pancreas of troglitazone-treated type 2 diabetic ZDF rats
한국실험동물학회 학술발표대회 논문집
2005 .06
-
Peroxisome Proliferator-Activated Receptor (PPAR) α/γ 작용제
대한내과학회지
2014 .01
-
Regulation of PPAR and SREBP-1C Through Exercise in White Adipose Tissue of Female C57BL/6J Mice
대한의생명과학회지
2012 .09
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2009-510-017357106