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Modulation of Immunosuppression by Oligonucleotide-Based Molecules and Small Molecules Targeting Myeloid-Derived Suppressor Cells
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논문 기본 정보

Type
Academic journal
Author
Lim, Jihyun (Department of Biological Science, Sookmyung Women's University) Lee, Aram (Department of Biological Science, Sookmyung Women's University) Lee, Hee Gu (Medical Genomics Research Center, Korea Research Institute of Bioscience and Biotechnology) Lim, Jong-Seok (Department of Biological Science, Sookmyung Women's University)
Journal
한국응용약물학회 Biomolecules & Therapeutics(구 응용약물학회지) Biomolecules & therapeutics 제28권 제1호 KCI Accredited Journals
Published
2020.1
Pages
1 - 17 (17page)

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Modulation of Immunosuppression by Oligonucleotide-Based Molecules and Small Molecules Targeting Myeloid-Derived Suppressor Cells
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Abstract· Keywords

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Myeloid-derived suppressor cells (MDSCs) are immature myeloid cells that exert suppressive function on the immune response. MDSCs expand in tumor-bearing hosts or in the tumor microenvironment and suppress T cell responses via various mechanisms, whereas a reduction in their activities has been observed in autoimmune diseases or infections. It has been reported that the symptoms of various diseases, including malignant tumors, can be alleviated by targeting MDSCs. Moreover, MDSCs can contribute to patient resistance to therapy using immune checkpoint inhibitors. In line with these therapeutic approaches, diverse oligonucleotide-based molecules and small molecules have been evaluated for their therapeutic efficacy in several disease models via the modulation of MDSC activity. In the current review, MDSC-targeting oligonucleotides and small molecules are briefly summarized, and we highlight the immunomodulatory effects on MDSCs in a variety of disease models and the application of MDSC-targeting molecules for immuno-oncologic therapy.
#Myeloid-derived suppressor cells #MDSCs) #Oligonucleotide-based molecules #Small molecules #Tumor microenvironment #Immune suppression #MDSC-targeting agents

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Abraham, S. M. / 2006 / Antiinflammatory effects of dexamethasone are partly dependent on induction of dual specificity phosphatase 1 / J. Exp. Med 203:1883~1889 google schola Ali, K. / 2014 / Inactivation of PI(3)K p110delta breaks regulatory T-cell-mediated immune tolerance to cancer / Nature 510:407~411 google schola Anchoori, R. K. / 2013 / A bis-benzylidine piperidone targeting proteasome ubiquitin receptor RPN13/ADRM1 as a therapy for cancer / Cancer Cell 24:791~805 google schola Arguello, F. / 1998 / Flavopiridol induces apoptosis of normal lymphoid cells, causes immunosuppression, and has potent antitumor activity In vivo against human leukemia and lymphoma xenografts / Blood 91:2482~2490 google schola Azoury, S. C. / 2016 / Molecularly targeted agents and immunotherapy for the treatment of head and neck squamous cell cancer(HNSCC) / Discov. Med 21:507~516 google schola

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