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논문 기본 정보

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학술저널
저자정보
Jahirul Islam (Seoul National University College of Medicine) Hack June Lee (Seoul National University College of Medicine,) Seung Hee Yang (Seoul National University Hospital) Dong Ki Kim (Seoul National University College of Medicine) Kwon Wook Joo (Seoul National University College of Medicine) Yon Su Kim (Seoul National University College of Medicine) Sang-Uk Seo (Seoul National University College of Medicine) Seung-Yong Seong (Seoul National University College of Medicine) Dong-Sup Lee (Seoul National University College of Medicine) Je-In Youn (Seoul National University College of Medicine) Seung Seok Han (Seoul National University College of Medicine)
저널정보
대한면역학회 Immune Network Immune Network Vol.20 No.2
발행연도
2020.4
수록면
120 - 130 (11page)

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Type 2 diabetic nephropathy (T2DN) progresses with an increasingly inflammatory milieu, wherein various immune cells are relevant. Herein, we investigated the levels of myeloidderived suppressor cells (MDSCs) and their clinical implication in patients with T2DN. A total of 91 subjects (T2DN, n=80; healthy, n=11) were recruited and their PBMCs were used for flow cytometric analysis of polymorphonuclear (PMN-) and monocytic (M-) MDSCs, in addition to other immune cell subsets. The risk of renal progression was evaluated according to the quartiles of MDSC levels using the Cox model. The proportion of MDSCs in T2DN patients was higher than in healthy individuals (median, 6.7% vs. 2.5%). PMNMDSCs accounted for 96% of MDSCs, and 78% of PMN-MDSCs expressed Lox-1. The expansion of PMN-MDSCs was not related to the stage of T2DN or other kidney disease parameters such as glomerular filtration rate and proteinuria. The production of ROS in PMN-MDSCs of patients was higher than in neutrophils of patients or in immune cells of healthy individuals, and this production was augmented under hyperglycemic conditions. The 4th quartile group of PMN-MDSCs had a higher risk of renal progression than the 1st quartile group, irrespective of adjusting for multiple clinical and laboratory variables. In conclusion, PMN-MDSCs are expanded in patients with T2DN, and may represent as an immunological biomarker of renal progression.
#Diabetic nephropathy #End-stage renal disease #Immunology #Monocyte #Myeloid-derived suppressor cell

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ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES

참고문헌 (34)

참고문헌 신청
Locatelli F / 2003 / The importance of diabetic nephropathy in current nephrological practice / Nephrol Dial Transplant 18:1716~1725 google schola Lok CE / 2004 / The growing volume of diabetes-related dialysis : a population based study / Nephrol Dial Transplant 19:3098~3103 google schola Chang YT / 2014 / Diabetes and end-stage renal disease synergistically contribute to increased incidence of cardiovascular events : a nationwide follow-up study during 1998–2009 / Diabetes Care 37:277~285 google schola Afkarian M / 2013 / Kidney disease and increased mortality risk in type 2 diabetes / J Am Soc Nephrol 24:302~308 google schola Nichols GA / 2011 / Medical care costs associated with progression of diabetic nephropathy / Diabetes Care 34:2374~2378 google schola

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